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Anti-FGF1/ AFGF/ ECGF functional antibody
Anti-FGF1/ AFGF/ ECGF functional antibody for cell culture, ELISA & in-vivo assay
Go to FGF1/FGF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T18639-Ab-1/ GM-Tg-hg-T18639-Ab-2 | Anti-Human FGF1 monoclonal antibody | Human |
| GM-Tg-rg-T18639-Ab-1/ GM-Tg-rg-T18639-Ab-2 | Anti-Rat FGF1 monoclonal antibody | Rat |
| GM-Tg-mg-T18639-Ab-1/ GM-Tg-mg-T18639-Ab-2 | Anti-Mouse FGF1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T18639-Ab-1/ GM-Tg-cynog-T18639-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGF1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T18639-Ab-1/ GM-Tg-felg-T18639-Ab-2 | Anti-Feline FGF1 monoclonal antibody | Feline |
| GM-Tg-cang-T18639-Ab-1/ GM-Tg-cang-T18639-Ab-2 | Anti-Canine FGF1 monoclonal antibody | Canine |
| GM-Tg-bovg-T18639-Ab-1/ GM-Tg-bovg-T18639-Ab-2 | Anti-Bovine FGF1 monoclonal antibody | Bovine |
| GM-Tg-equg-T18639-Ab-1/ GM-Tg-equg-T18639-Ab-2 | Anti-Equine FGF1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T18639-Ab-1/ GM-Tg-hg-T18639-Ab-2; GM-Tg-rg-T18639-Ab-1/ GM-Tg-rg-T18639-Ab-2; GM-Tg-mg-T18639-Ab-1/ GM-Tg-mg-T18639-Ab-2; GM-Tg-cynog-T18639-Ab-1/ GM-Tg-cynog-T18639-Ab-2; GM-Tg-felg-T18639-Ab-1/ GM-Tg-felg-T18639-Ab-2; GM-Tg-cang-T18639-Ab-1/ GM-Tg-cang-T18639-Ab-2; GM-Tg-bovg-T18639-Ab-1/ GM-Tg-bovg-T18639-Ab-2; GM-Tg-equg-T18639-Ab-1/ GM-Tg-equg-T18639-Ab-2 |
| Products Name | Anti-FGF1 monoclonal antibody |
| Format | mab |
| Target Name | FGF1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T18639-Ag-1 | Recombinant multi-species FGF1/ AFGF/ ECGF protein |
| Cytokine | GM-Tg-g-T18639-Ag-1 | fibroblast growth factor 1 (acidic) (FGF1) protein |
| ORF Viral Vector | pGMLP001937 | human FGF1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001937 | human FGF1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000086 | mouse Fgf1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000086 | mouse Fgf1 Lentivirus particle |
Target information
| Target ID | GM-T18639 |
| Target Name | FGF1 |
| Gene ID | 2246,14164,25317,705970,607724,101082206,281160,100033960 |
| Gene Symbol and Synonyms | AFGF,Dffrx,ECGF,ECGF-beta,ECGFA,ECGFB,EDGF,EDGF II,Fam,FGF-1,FGF-alpha,FGF1,Fgf2b,FGFA,GLIO703,HBGF-1,HBGF1 |
| Uniprot Accession | P05230,P61149,P18651,P03968 |
| Uniprot Entry Name | FGF1_HUMAN,FGF1_RAT,FGF1_CANLF,FGF1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000113578 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FGF1, gene name: FGF1, also named as AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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