Anti-HS90A/ HSP90A/ HSP90AA1 monoclonal antibody

Anti-HS90A/ HSP90A/ HSP90AA1 antibody for FACS & in-vivo assay

Target products collectionGo to HSP90A/HSP90AA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T18477-Ab-1/ GM-Tg-hg-T18477-Ab-2Anti-Human HSP90A/HSP90AA1 monoclonal antibodyHuman
GM-Tg-rg-T18477-Ab-1/ GM-Tg-rg-T18477-Ab-2Anti-Rat HSP90A/HSP90AA1 monoclonal antibodyRat
GM-Tg-mg-T18477-Ab-1/ GM-Tg-mg-T18477-Ab-2Anti-Mouse HSP90A/HSP90AA1 monoclonal antibodyMouse
GM-Tg-cynog-T18477-Ab-1/ GM-Tg-cynog-T18477-Ab-2Anti-Cynomolgus/ Rhesus macaque HSP90A/HSP90AA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T18477-Ab-1/ GM-Tg-felg-T18477-Ab-2Anti-Feline HSP90A/HSP90AA1 monoclonal antibodyFeline
GM-Tg-cang-T18477-Ab-1/ GM-Tg-cang-T18477-Ab-2Anti-Canine HSP90A/HSP90AA1 monoclonal antibodyCanine
GM-Tg-bovg-T18477-Ab-1/ GM-Tg-bovg-T18477-Ab-2Anti-Bovine HSP90A/HSP90AA1 monoclonal antibodyBovine
GM-Tg-equg-T18477-Ab-1/ GM-Tg-equg-T18477-Ab-2Anti-Equine HSP90A/HSP90AA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T18477-Ab-1/ GM-Tg-hg-T18477-Ab-2; GM-Tg-rg-T18477-Ab-1/ GM-Tg-rg-T18477-Ab-2;
GM-Tg-mg-T18477-Ab-1/ GM-Tg-mg-T18477-Ab-2; GM-Tg-cynog-T18477-Ab-1/ GM-Tg-cynog-T18477-Ab-2;
GM-Tg-felg-T18477-Ab-1/ GM-Tg-felg-T18477-Ab-2; GM-Tg-cang-T18477-Ab-1/ GM-Tg-cang-T18477-Ab-2;
GM-Tg-bovg-T18477-Ab-1/ GM-Tg-bovg-T18477-Ab-2; GM-Tg-equg-T18477-Ab-1/ GM-Tg-equg-T18477-Ab-2
Products NameAnti-HSP90A/HSP90AA1 monoclonal antibody
Formatmab
Target NameHSP90A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HSP90A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HS90A/ HSP90A/ HSP90AA1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000214human HSP90AA1 Lentivirus particle
    ORF Viral VectorpGMLV000214human HSP90AA1 Lentivirus plasmid
    ORF Viral VectorpGMLPm003576mouse Hsp90aa1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003576mouse Hsp90aa1 Lentivirus particle


    Target information

    Target IDGM-T18477
    Target NameHSP90A
    Gene ID3320,15519,299331,708431,480438,101094857,281832,100033837
    Gene Symbol and Synonyms86kDa,89kDa,EL52,HEL-S-65p,Hsp103,hsp4,HSP86,Hsp86-1,Hsp89,HSP89A,Hsp90,HSP90A,HSP90AA1,HSP90N,HSPC1,HSPCA,HSPCAL1,HSPCAL4,HSPN,LAP-2,LAP2
    Uniprot AccessionP07900,P82995,Q76LV2,Q9GKX7
    Uniprot Entry NameHS90A_HUMAN,HS90A_RAT,HS90A_BOVIN,HS90A_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseLung Cancer, Congenital occlusion of ureteropelvic junction
    Gene EnsemblENSG00000080824
    Target ClassificationN/A

    The target: HSP90A, gene name: HSP90AA1, also named as EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2. The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.