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Anti-IRE1a monoclonal antibody
Pre-made anti-IRE1a monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IRE1a/ERN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17656-Ab-1/ GM-Tg-hg-T17656-Ab-2 | Anti-Human IRE1a/ERN1 monoclonal antibody | Human |
| GM-Tg-rg-T17656-Ab-1/ GM-Tg-rg-T17656-Ab-2 | Anti-Rat IRE1a/ERN1 monoclonal antibody | Rat |
| GM-Tg-mg-T17656-Ab-1/ GM-Tg-mg-T17656-Ab-2 | Anti-Mouse IRE1a/ERN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T17656-Ab-1/ GM-Tg-cynog-T17656-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IRE1a/ERN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17656-Ab-1/ GM-Tg-felg-T17656-Ab-2 | Anti-Feline IRE1a/ERN1 monoclonal antibody | Feline |
| GM-Tg-cang-T17656-Ab-1/ GM-Tg-cang-T17656-Ab-2 | Anti-Canine IRE1a/ERN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T17656-Ab-1/ GM-Tg-bovg-T17656-Ab-2 | Anti-Bovine IRE1a/ERN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T17656-Ab-1/ GM-Tg-equg-T17656-Ab-2 | Anti-Equine IRE1a/ERN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17656-Ab-1/ GM-Tg-hg-T17656-Ab-2; GM-Tg-rg-T17656-Ab-1/ GM-Tg-rg-T17656-Ab-2; GM-Tg-mg-T17656-Ab-1/ GM-Tg-mg-T17656-Ab-2; GM-Tg-cynog-T17656-Ab-1/ GM-Tg-cynog-T17656-Ab-2; GM-Tg-felg-T17656-Ab-1/ GM-Tg-felg-T17656-Ab-2; GM-Tg-cang-T17656-Ab-1/ GM-Tg-cang-T17656-Ab-2; GM-Tg-bovg-T17656-Ab-1/ GM-Tg-bovg-T17656-Ab-2; GM-Tg-equg-T17656-Ab-1/ GM-Tg-equg-T17656-Ab-2 |
| Products Name | Anti-IRE1a/ERN1 monoclonal antibody |
| Format | mab |
| Target Name | IRE1a |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IRE1a monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T17656-Ag-1 | Recombinant multi-species ERN1/ IRE1a/ IRE1 protein |
Target information
| Target ID | GM-T17656 |
| Target Name | IRE1a |
| Gene ID | 2081,78943,498013,717751,610766,101084148,112442685,100064339 |
| Gene Symbol and Synonyms | 9030414B18Rik,ERN1,hIRE1p,IRE1,IRE1a,Ire1alpha,IRE1P,RGD1559716 |
| Uniprot Accession | O75460 |
| Uniprot Entry Name | ERN1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000178607 |
| Target Classification | Kinase |
The target: IRE1a, gene name: ERN1, also named as IRE1, IRE1P, IRE1a, hIRE1p. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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