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Anti-DHFR monoclonal antibody
Pre-made anti-DHFR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DHFR/DHFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17345-Ab-1/ GM-Tg-hg-T17345-Ab-2 | Anti-Human DHFR monoclonal antibody | Human |
| GM-Tg-rg-T17345-Ab-1/ GM-Tg-rg-T17345-Ab-2 | Anti-Rat DHFR monoclonal antibody | Rat |
| GM-Tg-mg-T17345-Ab-1/ GM-Tg-mg-T17345-Ab-2 | Anti-Mouse DHFR monoclonal antibody | Mouse |
| GM-Tg-cynog-T17345-Ab-1/ GM-Tg-cynog-T17345-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DHFR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17345-Ab-1/ GM-Tg-felg-T17345-Ab-2 | Anti-Feline DHFR monoclonal antibody | Feline |
| GM-Tg-cang-T17345-Ab-1/ GM-Tg-cang-T17345-Ab-2 | Anti-Canine DHFR monoclonal antibody | Canine |
| GM-Tg-bovg-T17345-Ab-1/ GM-Tg-bovg-T17345-Ab-2 | Anti-Bovine DHFR monoclonal antibody | Bovine |
| GM-Tg-equg-T17345-Ab-1/ GM-Tg-equg-T17345-Ab-2 | Anti-Equine DHFR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17345-Ab-1/ GM-Tg-hg-T17345-Ab-2; GM-Tg-rg-T17345-Ab-1/ GM-Tg-rg-T17345-Ab-2; GM-Tg-mg-T17345-Ab-1/ GM-Tg-mg-T17345-Ab-2; GM-Tg-cynog-T17345-Ab-1/ GM-Tg-cynog-T17345-Ab-2; GM-Tg-felg-T17345-Ab-1/ GM-Tg-felg-T17345-Ab-2; GM-Tg-cang-T17345-Ab-1/ GM-Tg-cang-T17345-Ab-2; GM-Tg-bovg-T17345-Ab-1/ GM-Tg-bovg-T17345-Ab-2; GM-Tg-equg-T17345-Ab-1/ GM-Tg-equg-T17345-Ab-2 |
| Products Name | Anti-DHFR monoclonal antibody |
| Format | mab |
| Target Name | DHFR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DHFR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T17345-Ag-1 | Recombinant multi-species DYR/ DHFR/ DHFRP1 protein |
| ORF Viral Vector | vGMLP000510 | human DHFR Lentivirus particle |
| ORF Viral Vector | vGMAP000102 | Human DHFR Adenovirus particle |
| ORF Viral Vector | pGMAP000102 | Human DHFR Adenovirus plasmid |
| ORF Viral Vector | pGMLP000510 | human DHFR Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000076 | mouse Dhfr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000076 | mouse Dhfr Lentivirus particle |
Target information
| Target ID | GM-T17345 |
| Target Name | DHFR |
| Gene ID | 1719,13361,24312,711268,479165,101087964,508809,100073256 |
| Gene Symbol and Synonyms | 8430436I03Rik,DHFR,DHFR1,DHFRP1,DYR |
| Uniprot Accession | P00374,Q920D2,P00376 |
| Uniprot Entry Name | DYR_HUMAN,DYR_RAT,DYR_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000228716 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DHFR, gene name: DHFR, also named as DHFRP1, DYR. Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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