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Anti-CCR1/ CD191/ CKR-1 monoclonal antibody
Anti-CCR1/ CD191/ CKR-1 antibody for FACS & in-vivo assay
Go to CCR1/CCR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T16016-Ab-1/ GM-Tg-hg-T16016-Ab-2 | Anti-Human CCR1 monoclonal antibody | Human |
| GM-Tg-rg-T16016-Ab-1/ GM-Tg-rg-T16016-Ab-2 | Anti-Rat CCR1 monoclonal antibody | Rat |
| GM-Tg-mg-T16016-Ab-1/ GM-Tg-mg-T16016-Ab-2 | Anti-Mouse CCR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T16016-Ab-1/ GM-Tg-cynog-T16016-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T16016-Ab-1/ GM-Tg-felg-T16016-Ab-2 | Anti-Feline CCR1 monoclonal antibody | Feline |
| GM-Tg-cang-T16016-Ab-1/ GM-Tg-cang-T16016-Ab-2 | Anti-Canine CCR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T16016-Ab-1/ GM-Tg-bovg-T16016-Ab-2 | Anti-Bovine CCR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T16016-Ab-1/ GM-Tg-equg-T16016-Ab-2 | Anti-Equine CCR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T16016-Ab-1/ GM-Tg-hg-T16016-Ab-2; GM-Tg-rg-T16016-Ab-1/ GM-Tg-rg-T16016-Ab-2; GM-Tg-mg-T16016-Ab-1/ GM-Tg-mg-T16016-Ab-2; GM-Tg-cynog-T16016-Ab-1/ GM-Tg-cynog-T16016-Ab-2; GM-Tg-felg-T16016-Ab-1/ GM-Tg-felg-T16016-Ab-2; GM-Tg-cang-T16016-Ab-1/ GM-Tg-cang-T16016-Ab-2; GM-Tg-bovg-T16016-Ab-1/ GM-Tg-bovg-T16016-Ab-2; GM-Tg-equg-T16016-Ab-1/ GM-Tg-equg-T16016-Ab-2 |
| Products Name | Anti-CCR1 monoclonal antibody |
| Format | mab |
| Target Name | CCR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR1/ CD191/ CKR-1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T16016-Ag-1 | chemokine (C-C motif) receptor 1 (CCR1) protein |
| ORF Viral Vector | vGMLP000541 | human CCR1 Lentivirus particle |
| ORF Viral Vector | vGMAP000400 | Human CCR1 Adenovirus particle |
| ORF Viral Vector | pGMAP000400 | Human CCR1 Adenovirus plasmid |
| ORF Viral Vector | pGMLP000541 | human CCR1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001969 | mouse Ccr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001969 | mouse Ccr1 Lentivirus particle |
Target information
| Target ID | GM-T16016 |
| Target Name | CCR1 |
| Gene ID | 1230,12768,57301,574188,484791,100191004,407771,100065466 |
| Gene Symbol and Synonyms | CCR1,CD191,CKR-1,CKR1,CMKBR1,HM145,Mip-1a-R,MIP1aR,SCYAR1 |
| Uniprot Accession | P32246,P56482 |
| Uniprot Entry Name | CCR1_HUMAN,CCR1_MACMU |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000163823 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: CCR1, gene name: CCR1, also named as CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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