Anti-PAI1/ SERPINE1/ PAI monoclonal antibody

Anti-PAI1/ SERPINE1/ PAI antibody for FACS & in-vivo assay

Target products collectionGo to SERPINE1/SERPINE1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T15556-Ab-1/ GM-Tg-hg-T15556-Ab-2Anti-Human SERPINE1 monoclonal antibodyHuman
GM-Tg-rg-T15556-Ab-1/ GM-Tg-rg-T15556-Ab-2Anti-Rat SERPINE1 monoclonal antibodyRat
GM-Tg-mg-T15556-Ab-1/ GM-Tg-mg-T15556-Ab-2Anti-Mouse SERPINE1 monoclonal antibodyMouse
GM-Tg-cynog-T15556-Ab-1/ GM-Tg-cynog-T15556-Ab-2Anti-Cynomolgus/ Rhesus macaque SERPINE1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T15556-Ab-1/ GM-Tg-felg-T15556-Ab-2Anti-Feline SERPINE1 monoclonal antibodyFeline
GM-Tg-cang-T15556-Ab-1/ GM-Tg-cang-T15556-Ab-2Anti-Canine SERPINE1 monoclonal antibodyCanine
GM-Tg-bovg-T15556-Ab-1/ GM-Tg-bovg-T15556-Ab-2Anti-Bovine SERPINE1 monoclonal antibodyBovine
GM-Tg-equg-T15556-Ab-1/ GM-Tg-equg-T15556-Ab-2Anti-Equine SERPINE1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T15556-Ab-1/ GM-Tg-hg-T15556-Ab-2; GM-Tg-rg-T15556-Ab-1/ GM-Tg-rg-T15556-Ab-2;
GM-Tg-mg-T15556-Ab-1/ GM-Tg-mg-T15556-Ab-2; GM-Tg-cynog-T15556-Ab-1/ GM-Tg-cynog-T15556-Ab-2;
GM-Tg-felg-T15556-Ab-1/ GM-Tg-felg-T15556-Ab-2; GM-Tg-cang-T15556-Ab-1/ GM-Tg-cang-T15556-Ab-2;
GM-Tg-bovg-T15556-Ab-1/ GM-Tg-bovg-T15556-Ab-2; GM-Tg-equg-T15556-Ab-1/ GM-Tg-equg-T15556-Ab-2
Products NameAnti-SERPINE1 monoclonal antibody
Formatmab
Target NameSERPINE1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SERPINE1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PAI1/ SERPINE1/ PAI VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T15556-Ag-1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) protein
    ORF Viral VectorvGMAP000049Human SERPINE1 Adenovirus particle
    ORF Viral VectorpGMAP000049Human SERPINE1 Adenovirus plasmid
    ORF Viral VectorvGMLP000493human SERPINE1 Lentivirus particle
    ORF Viral VectorpGMLP000493human SERPINE1 Lentivirus plasmid
    ORF Viral VectorpGMLPm002084mouse Serpine1 Lentivirus plasmid
    ORF Viral VectorvGMLPm002084mouse Serpine1 Lentivirus particle


    Target information

    Target IDGM-T15556
    Target NameSERPINE1
    Gene ID5054,18787,24617,713883,403476,100127105,281375,100033931
    Gene Symbol and SynonymsPAI,PAI-1,PAI1,PAI1A,Pai1aa,Planh,PLANH1,RATPAI1A,SERPINE1
    Uniprot AccessionP05121,P20961,P13909
    Uniprot Entry NamePAI1_HUMAN,PAI1_RAT,PAI1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseOvary Cancer, Malignant neoplasm of bladder
    Gene EnsemblENSG00000106366
    Target ClassificationN/A

    The target: SERPINE1, gene name: SERPINE1, also named as PAI, PAI-1, PAI1, PLANH1. This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.