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Anti-FAK monoclonal antibody
Pre-made anti-FAK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FAK/PTK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T15068-Ab-1/ GM-Tg-hg-T15068-Ab-2 | Anti-Human FAK/PTK2 monoclonal antibody | Human |
| GM-Tg-rg-T15068-Ab-1/ GM-Tg-rg-T15068-Ab-2 | Anti-Rat FAK/PTK2 monoclonal antibody | Rat |
| GM-Tg-mg-T15068-Ab-1/ GM-Tg-mg-T15068-Ab-2 | Anti-Mouse FAK/PTK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T15068-Ab-1/ GM-Tg-cynog-T15068-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FAK/PTK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T15068-Ab-1/ GM-Tg-felg-T15068-Ab-2 | Anti-Feline FAK/PTK2 monoclonal antibody | Feline |
| GM-Tg-cang-T15068-Ab-1/ GM-Tg-cang-T15068-Ab-2 | Anti-Canine FAK/PTK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T15068-Ab-1/ GM-Tg-bovg-T15068-Ab-2 | Anti-Bovine FAK/PTK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T15068-Ab-1/ GM-Tg-equg-T15068-Ab-2 | Anti-Equine FAK/PTK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T15068-Ab-1/ GM-Tg-hg-T15068-Ab-2; GM-Tg-rg-T15068-Ab-1/ GM-Tg-rg-T15068-Ab-2; GM-Tg-mg-T15068-Ab-1/ GM-Tg-mg-T15068-Ab-2; GM-Tg-cynog-T15068-Ab-1/ GM-Tg-cynog-T15068-Ab-2; GM-Tg-felg-T15068-Ab-1/ GM-Tg-felg-T15068-Ab-2; GM-Tg-cang-T15068-Ab-1/ GM-Tg-cang-T15068-Ab-2; GM-Tg-bovg-T15068-Ab-1/ GM-Tg-bovg-T15068-Ab-2; GM-Tg-equg-T15068-Ab-1/ GM-Tg-equg-T15068-Ab-2 |
| Products Name | Anti-FAK/PTK2 monoclonal antibody |
| Format | mab |
| Target Name | FAK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FAK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T15068-Ag-1 | Recombinant multi-species FAK1/ FAK/ PTK2 protein |
| ORF Viral Vector | vGMLV000556 | human PTK2 Lentivirus particle |
| ORF Viral Vector | pGMLV000556 | human PTK2 Lentivirus plasmid |
Target information
| Target ID | GM-T15068 |
| Target Name | FAK |
| Gene ID | 5747,14083,25614,700634,475108,101095952,506270,100058245 |
| Gene Symbol and Synonyms | FADK,FADK 1,FAK,FAK1,FRNK,p125FAK,pp125FAK,PPP1R71,PTK2 |
| Uniprot Accession | Q05397,O35346 |
| Uniprot Entry Name | FAK1_HUMAN,FAK1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000169398 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: FAK, gene name: PTK2, also named as FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK. This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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