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Anti-IBP1/ IGFBP1/ AFBP functional antibody
Anti-IBP1/ IGFBP1/ AFBP functional antibody for cell culture, ELISA & in-vivo assay
Go to IGFBP1/IGFBP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T15048-Ab-1/ GM-Tg-hg-T15048-Ab-2 | Anti-Human IGFBP1 monoclonal antibody | Human |
| GM-Tg-rg-T15048-Ab-1/ GM-Tg-rg-T15048-Ab-2 | Anti-Rat IGFBP1 monoclonal antibody | Rat |
| GM-Tg-mg-T15048-Ab-1/ GM-Tg-mg-T15048-Ab-2 | Anti-Mouse IGFBP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T15048-Ab-1/ GM-Tg-cynog-T15048-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGFBP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T15048-Ab-1/ GM-Tg-felg-T15048-Ab-2 | Anti-Feline IGFBP1 monoclonal antibody | Feline |
| GM-Tg-cang-T15048-Ab-1/ GM-Tg-cang-T15048-Ab-2 | Anti-Canine IGFBP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T15048-Ab-1/ GM-Tg-bovg-T15048-Ab-2 | Anti-Bovine IGFBP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T15048-Ab-1/ GM-Tg-equg-T15048-Ab-2 | Anti-Equine IGFBP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T15048-Ab-1/ GM-Tg-hg-T15048-Ab-2; GM-Tg-rg-T15048-Ab-1/ GM-Tg-rg-T15048-Ab-2; GM-Tg-mg-T15048-Ab-1/ GM-Tg-mg-T15048-Ab-2; GM-Tg-cynog-T15048-Ab-1/ GM-Tg-cynog-T15048-Ab-2; GM-Tg-felg-T15048-Ab-1/ GM-Tg-felg-T15048-Ab-2; GM-Tg-cang-T15048-Ab-1/ GM-Tg-cang-T15048-Ab-2; GM-Tg-bovg-T15048-Ab-1/ GM-Tg-bovg-T15048-Ab-2; GM-Tg-equg-T15048-Ab-1/ GM-Tg-equg-T15048-Ab-2 |
| Products Name | Anti-IGFBP1 monoclonal antibody |
| Format | mab |
| Target Name | IGFBP1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGFBP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T15048-Ag-1 | Recombinant multi-species IBP1/ IGFBP1/ AFBP protein |
| Cytokine | GM-Tg-g-T15048-Ag-1 | insulin-like growth factor binding protein 1 (IGFBP1) protein |
| ORF Viral Vector | vGMLP004491 | human IGFBP1 Lentivirus particle |
| ORF Viral Vector | pGMLP004491 | human IGFBP1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000904 | mouse Igfbp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000904 | mouse Igfbp1 Lentivirus particle |
Target information
| Target ID | GM-T15048 |
| Target Name | IGFBP1 |
| Gene ID | 3484,16006,25685,696994,480812,101101629,282259,100034154 |
| Gene Symbol and Synonyms | AFBP,hIGFBP-1,IBP1,IGF-BP25,IGFBA,IGFBP-1,IGFBP1,PP12 |
| Uniprot Accession | P08833,P21743,P24591 |
| Uniprot Entry Name | IBP1_HUMAN,IBP1_RAT,IBP1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker, Cytokine Target |
| Disease | Ovary Cancer, Non-small cell lung carcinoma |
| Gene Ensembl | ENSG00000146678 |
| Target Classification | N/A |
The target: IGFBP1, gene name: IGFBP1, also named as AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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