Anti-I10R2/ IL10RB/ CDW210B monoclonal antibody

Anti-I10R2/ IL10RB/ CDW210B antibody for FACS & in-vivo assay

Target products collectionGo to IL10RB/IL10RB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14557-Ab-1/ GM-Tg-hg-T14557-Ab-2Anti-Human IL10RB monoclonal antibodyHuman
GM-Tg-rg-T14557-Ab-1/ GM-Tg-rg-T14557-Ab-2Anti-Rat IL10RB monoclonal antibodyRat
GM-Tg-mg-T14557-Ab-1/ GM-Tg-mg-T14557-Ab-2Anti-Mouse IL10RB monoclonal antibodyMouse
GM-Tg-cynog-T14557-Ab-1/ GM-Tg-cynog-T14557-Ab-2Anti-Cynomolgus/ Rhesus macaque IL10RB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14557-Ab-1/ GM-Tg-felg-T14557-Ab-2Anti-Feline IL10RB monoclonal antibodyFeline
GM-Tg-cang-T14557-Ab-1/ GM-Tg-cang-T14557-Ab-2Anti-Canine IL10RB monoclonal antibodyCanine
GM-Tg-bovg-T14557-Ab-1/ GM-Tg-bovg-T14557-Ab-2Anti-Bovine IL10RB monoclonal antibodyBovine
GM-Tg-equg-T14557-Ab-1/ GM-Tg-equg-T14557-Ab-2Anti-Equine IL10RB monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14557-Ab-1/ GM-Tg-hg-T14557-Ab-2; GM-Tg-rg-T14557-Ab-1/ GM-Tg-rg-T14557-Ab-2;
GM-Tg-mg-T14557-Ab-1/ GM-Tg-mg-T14557-Ab-2; GM-Tg-cynog-T14557-Ab-1/ GM-Tg-cynog-T14557-Ab-2;
GM-Tg-felg-T14557-Ab-1/ GM-Tg-felg-T14557-Ab-2; GM-Tg-cang-T14557-Ab-1/ GM-Tg-cang-T14557-Ab-2;
GM-Tg-bovg-T14557-Ab-1/ GM-Tg-bovg-T14557-Ab-2; GM-Tg-equg-T14557-Ab-1/ GM-Tg-equg-T14557-Ab-2
Products NameAnti-IL10RB monoclonal antibody
Formatmab
Target NameIL10RB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL10RB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-819Pre-Made Eflepedocokin Alfa Biosimilar, Fusion Protein targeting IL10RB fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CDW210B/CRF2-4/CRFB4/D21S58/D21S66/IL-10R2
    Target AntigenProducts DevelopingMulti-species I10R2/ IL10RB/ CDW210B VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T14557-Ag-1interleukin 10 receptor, beta (IL10RB) protein
    ORF Viral VectorpGMLP004604human IL10RB Lentivirus plasmid
    ORF Viral VectorvGMLP004604human IL10RB Lentivirus particle
    ORF Viral VectorpGMLPm002089mouse Il10rb Lentivirus plasmid
    ORF Viral VectorvGMLPm002089mouse Il10rb Lentivirus particle


    Target information

    Target IDGM-T14557
    Target NameIL10RB
    Gene ID3588,16155,304091,706012,478404,101090038,767864,100052549
    Gene Symbol and Synonyms6620401D04Rik,CDW210B,CRF2-4,CRFB4,D16H21S58,D21S58,D21S58h,D21S66,IBD25,IL-10R2,IL-10RB,Il10r2,IL10RB,RGD1560373
    Uniprot AccessionQ08334
    Uniprot Entry NameI10R2_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000243646
    Target ClassificationN/A

    The target: IL10RB, gene name: IL10RB, also named as CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2. The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.