Anti-S6A11/ SLC6A11/ GAT-3 monoclonal antibody

Anti-S6A11/ SLC6A11/ GAT-3 antibody for FACS & in-vivo assay

Target products collectionGo to SLC6A11/SLC6A11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14252-Ab-1/ GM-Tg-hg-T14252-Ab-2Anti-Human SLC6A11 monoclonal antibodyHuman
GM-Tg-rg-T14252-Ab-1/ GM-Tg-rg-T14252-Ab-2Anti-Rat SLC6A11 monoclonal antibodyRat
GM-Tg-mg-T14252-Ab-1/ GM-Tg-mg-T14252-Ab-2Anti-Mouse SLC6A11 monoclonal antibodyMouse
GM-Tg-cynog-T14252-Ab-1/ GM-Tg-cynog-T14252-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC6A11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14252-Ab-1/ GM-Tg-felg-T14252-Ab-2Anti-Feline SLC6A11 monoclonal antibodyFeline
GM-Tg-cang-T14252-Ab-1/ GM-Tg-cang-T14252-Ab-2Anti-Canine SLC6A11 monoclonal antibodyCanine
GM-Tg-bovg-T14252-Ab-1/ GM-Tg-bovg-T14252-Ab-2Anti-Bovine SLC6A11 monoclonal antibodyBovine
GM-Tg-equg-T14252-Ab-1/ GM-Tg-equg-T14252-Ab-2Anti-Equine SLC6A11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14252-Ab-1/ GM-Tg-hg-T14252-Ab-2; GM-Tg-rg-T14252-Ab-1/ GM-Tg-rg-T14252-Ab-2;
GM-Tg-mg-T14252-Ab-1/ GM-Tg-mg-T14252-Ab-2; GM-Tg-cynog-T14252-Ab-1/ GM-Tg-cynog-T14252-Ab-2;
GM-Tg-felg-T14252-Ab-1/ GM-Tg-felg-T14252-Ab-2; GM-Tg-cang-T14252-Ab-1/ GM-Tg-cang-T14252-Ab-2;
GM-Tg-bovg-T14252-Ab-1/ GM-Tg-bovg-T14252-Ab-2; GM-Tg-equg-T14252-Ab-1/ GM-Tg-equg-T14252-Ab-2
Products NameAnti-SLC6A11 monoclonal antibody
Formatmab
Target NameSLC6A11
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC6A11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species S6A11/ SLC6A11/ GAT-3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T14252
    Target NameSLC6A11
    Gene ID6538,243616,79213,696741,476534,101092834,616071,100057720
    Gene Symbol and SynonymsD930045G19Rik,E130202I16Rik,Gabt4,GAT-3,GAT3,GAT4,SLC6A11
    Uniprot AccessionP48066,P31647
    Uniprot Entry NameS6A11_HUMAN,S6A11_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000132164
    Target ClassificationN/A

    The target: SLC6A11, gene name: SLC6A11, also named as GAT-3, GAT3, GAT4. The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.