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Anti-KLOTB/ KLB/ BKL monoclonal antibody
Anti-KLOTB/ KLB/ BKL antibody for FACS & in-vivo assay
Go to KLB/KLB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T14110-Ab-1/ GM-Tg-hg-T14110-Ab-2 | Anti-Human KLB monoclonal antibody | Human |
| GM-Tg-rg-T14110-Ab-1/ GM-Tg-rg-T14110-Ab-2 | Anti-Rat KLB monoclonal antibody | Rat |
| GM-Tg-mg-T14110-Ab-1/ GM-Tg-mg-T14110-Ab-2 | Anti-Mouse KLB monoclonal antibody | Mouse |
| GM-Tg-cynog-T14110-Ab-1/ GM-Tg-cynog-T14110-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KLB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T14110-Ab-1/ GM-Tg-felg-T14110-Ab-2 | Anti-Feline KLB monoclonal antibody | Feline |
| GM-Tg-cang-T14110-Ab-1/ GM-Tg-cang-T14110-Ab-2 | Anti-Canine KLB monoclonal antibody | Canine |
| GM-Tg-bovg-T14110-Ab-1/ GM-Tg-bovg-T14110-Ab-2 | Anti-Bovine KLB monoclonal antibody | Bovine |
| GM-Tg-equg-T14110-Ab-1/ GM-Tg-equg-T14110-Ab-2 | Anti-Equine KLB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T14110-Ab-1/ GM-Tg-hg-T14110-Ab-2; GM-Tg-rg-T14110-Ab-1/ GM-Tg-rg-T14110-Ab-2; GM-Tg-mg-T14110-Ab-1/ GM-Tg-mg-T14110-Ab-2; GM-Tg-cynog-T14110-Ab-1/ GM-Tg-cynog-T14110-Ab-2; GM-Tg-felg-T14110-Ab-1/ GM-Tg-felg-T14110-Ab-2; GM-Tg-cang-T14110-Ab-1/ GM-Tg-cang-T14110-Ab-2; GM-Tg-bovg-T14110-Ab-1/ GM-Tg-bovg-T14110-Ab-2; GM-Tg-equg-T14110-Ab-1/ GM-Tg-equg-T14110-Ab-2 |
| Products Name | Anti-KLB monoclonal antibody |
| Format | mab |
| Target Name | KLB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KLB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KLOTB/ KLB/ BKL VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T14110-Ag-1 | klotho beta (KLB) protein |
Target information
| Target ID | GM-T14110 |
| Target Name | KLB |
| Gene ID | 152831,83379,289625,699115,479110,101083930,514925,100064228 |
| Gene Symbol and Synonyms | AABR07015003.1,betaKlotho,BKL,KLB,Klb-ps1,RGD1308227 |
| Uniprot Accession | Q86Z14 |
| Uniprot Entry Name | KLOTB_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000134962 |
| Target Classification | N/A |
The target: KLB, gene name: KLB, also named as BKL. Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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