Anti-ITB7/ ITGB7 monoclonal antibody

Anti-ITB7/ ITGB7 antibody for FACS & in-vivo assay

Target products collectionGo to ITGB7/ITGB7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14065-Ab-1/ GM-Tg-hg-T14065-Ab-2Anti-Human ITGB7 monoclonal antibodyHuman
GM-Tg-rg-T14065-Ab-1/ GM-Tg-rg-T14065-Ab-2Anti-Rat ITGB7 monoclonal antibodyRat
GM-Tg-mg-T14065-Ab-1/ GM-Tg-mg-T14065-Ab-2Anti-Mouse ITGB7 monoclonal antibodyMouse
GM-Tg-cynog-T14065-Ab-1/ GM-Tg-cynog-T14065-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGB7 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14065-Ab-1/ GM-Tg-felg-T14065-Ab-2Anti-Feline ITGB7 monoclonal antibodyFeline
GM-Tg-cang-T14065-Ab-1/ GM-Tg-cang-T14065-Ab-2Anti-Canine ITGB7 monoclonal antibodyCanine
GM-Tg-bovg-T14065-Ab-1/ GM-Tg-bovg-T14065-Ab-2Anti-Bovine ITGB7 monoclonal antibodyBovine
GM-Tg-equg-T14065-Ab-1/ GM-Tg-equg-T14065-Ab-2Anti-Equine ITGB7 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14065-Ab-1/ GM-Tg-hg-T14065-Ab-2; GM-Tg-rg-T14065-Ab-1/ GM-Tg-rg-T14065-Ab-2;
GM-Tg-mg-T14065-Ab-1/ GM-Tg-mg-T14065-Ab-2; GM-Tg-cynog-T14065-Ab-1/ GM-Tg-cynog-T14065-Ab-2;
GM-Tg-felg-T14065-Ab-1/ GM-Tg-felg-T14065-Ab-2; GM-Tg-cang-T14065-Ab-1/ GM-Tg-cang-T14065-Ab-2;
GM-Tg-bovg-T14065-Ab-1/ GM-Tg-bovg-T14065-Ab-2; GM-Tg-equg-T14065-Ab-1/ GM-Tg-equg-T14065-Ab-2
Products NameAnti-ITGB7 monoclonal antibody
Formatmab
Target NameITGB7
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGB7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-616Pre-Made Vedolizumab biosimilar, Whole mAb, Anti-ITGA4;ITGB7 Antibody: Anti-CD49D/IA4 therapeutic antibody
    BiosimilarGMP-Bios-ab-200Pre-Made Etrolizumab biosimilar, Whole Mab: Anti-ITGA4;ITGB7;ITGAE;ITGB7 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ITB7/ ITGB7 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000442human ITGB7 Lentivirus particle
    ORF Viral VectorpGMLV000442human ITGB7 Lentivirus plasmid


    Target information

    Target IDGM-T14065
    Target NameITGB7
    Gene ID3695,16421,25713,699405,477598,101099982,514031,100063747
    Gene Symbol and SynonymsITGB7,Ly69
    Uniprot AccessionP26010
    Uniprot Entry NameITB7_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000139626
    Target ClassificationCheckpoint-Immuno Oncology

    The target: ITGB7, gene name: ITGB7, also named as . This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].



    About Gmab

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    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.