Anti-GALR2/ GAL2-R/ GALNR2 monoclonal antibody

Anti-GALR2/ GAL2-R/ GALNR2 antibody for FACS & in-vivo assay

Target products collectionGo to GAL2-R/GALR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T13453-Ab-1/ GM-Tg-hg-T13453-Ab-2Anti-Human GAL2-R/GALR2 monoclonal antibodyHuman
GM-Tg-rg-T13453-Ab-1/ GM-Tg-rg-T13453-Ab-2Anti-Rat GAL2-R/GALR2 monoclonal antibodyRat
GM-Tg-mg-T13453-Ab-1/ GM-Tg-mg-T13453-Ab-2Anti-Mouse GAL2-R/GALR2 monoclonal antibodyMouse
GM-Tg-cynog-T13453-Ab-1/ GM-Tg-cynog-T13453-Ab-2Anti-Cynomolgus/ Rhesus macaque GAL2-R/GALR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T13453-Ab-1/ GM-Tg-felg-T13453-Ab-2Anti-Feline GAL2-R/GALR2 monoclonal antibodyFeline
GM-Tg-cang-T13453-Ab-1/ GM-Tg-cang-T13453-Ab-2Anti-Canine GAL2-R/GALR2 monoclonal antibodyCanine
GM-Tg-bovg-T13453-Ab-1/ GM-Tg-bovg-T13453-Ab-2Anti-Bovine GAL2-R/GALR2 monoclonal antibodyBovine
GM-Tg-equg-T13453-Ab-1/ GM-Tg-equg-T13453-Ab-2Anti-Equine GAL2-R/GALR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T13453-Ab-1/ GM-Tg-hg-T13453-Ab-2; GM-Tg-rg-T13453-Ab-1/ GM-Tg-rg-T13453-Ab-2;
GM-Tg-mg-T13453-Ab-1/ GM-Tg-mg-T13453-Ab-2; GM-Tg-cynog-T13453-Ab-1/ GM-Tg-cynog-T13453-Ab-2;
GM-Tg-felg-T13453-Ab-1/ GM-Tg-felg-T13453-Ab-2; GM-Tg-cang-T13453-Ab-1/ GM-Tg-cang-T13453-Ab-2;
GM-Tg-bovg-T13453-Ab-1/ GM-Tg-bovg-T13453-Ab-2; GM-Tg-equg-T13453-Ab-1/ GM-Tg-equg-T13453-Ab-2
Products NameAnti-GAL2-R/GALR2 monoclonal antibody
Formatmab
Target NameGAL2-R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GAL2-R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GALR2/ GAL2-R/ GALNR2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001510human GALR2 Lentivirus particle
    ORF Viral VectorpGMLP001510human GALR2 Lentivirus plasmid
    ORF Viral VectorpGMLPm005279mouse Galr2 Lentivirus plasmid
    ORF Viral VectorvGMLPm005279mouse Galr2 Lentivirus particle


    Target information

    Target IDGM-T13453
    Target NameGAL2-R
    Gene ID8811,14428,29234,705684,483325,101096429,618629,100051251
    Gene Symbol and SynonymsGAL2-R,GALNR2,GALR-2,GALR2,mGalR
    Uniprot AccessionO43603,O08726
    Uniprot Entry NameGALR2_HUMAN,GALR2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000182687
    Target ClassificationGPCR

    The target: GAL2-R, gene name: GALR2, also named as GAL2-R, GALNR2, GALR-2. Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.