Anti-CYP19A1 monoclonal antibody

Pre-made anti-CYP19A1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to CYP19A1/CYP19A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T13260-Ab-1/ GM-Tg-hg-T13260-Ab-2Anti-Human CYP19A1 monoclonal antibodyHuman
GM-Tg-rg-T13260-Ab-1/ GM-Tg-rg-T13260-Ab-2Anti-Rat CYP19A1 monoclonal antibodyRat
GM-Tg-mg-T13260-Ab-1/ GM-Tg-mg-T13260-Ab-2Anti-Mouse CYP19A1 monoclonal antibodyMouse
GM-Tg-cynog-T13260-Ab-1/ GM-Tg-cynog-T13260-Ab-2Anti-Cynomolgus/ Rhesus macaque CYP19A1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T13260-Ab-1/ GM-Tg-felg-T13260-Ab-2Anti-Feline CYP19A1 monoclonal antibodyFeline
GM-Tg-cang-T13260-Ab-1/ GM-Tg-cang-T13260-Ab-2Anti-Canine CYP19A1 monoclonal antibodyCanine
GM-Tg-bovg-T13260-Ab-1/ GM-Tg-bovg-T13260-Ab-2Anti-Bovine CYP19A1 monoclonal antibodyBovine
GM-Tg-equg-T13260-Ab-1/ GM-Tg-equg-T13260-Ab-2Anti-Equine CYP19A1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T13260-Ab-1/ GM-Tg-hg-T13260-Ab-2; GM-Tg-rg-T13260-Ab-1/ GM-Tg-rg-T13260-Ab-2;
GM-Tg-mg-T13260-Ab-1/ GM-Tg-mg-T13260-Ab-2; GM-Tg-cynog-T13260-Ab-1/ GM-Tg-cynog-T13260-Ab-2;
GM-Tg-felg-T13260-Ab-1/ GM-Tg-felg-T13260-Ab-2; GM-Tg-cang-T13260-Ab-1/ GM-Tg-cang-T13260-Ab-2;
GM-Tg-bovg-T13260-Ab-1/ GM-Tg-bovg-T13260-Ab-2; GM-Tg-equg-T13260-Ab-1/ GM-Tg-equg-T13260-Ab-2
Products NameAnti-CYP19A1 monoclonal antibody
Formatmab
Target NameCYP19A1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-CYP19A1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T13260-Ag-1Recombinant multi-species CP19A/ CYP19A1/ ARO protein
    ORF Viral VectorpGMLV000457human CYP19A1 Lentivirus plasmid
    ORF Viral VectorpGMAP000276Human CYP19A1 Adenovirus plasmid
    ORF Viral VectorvGMLV000457human CYP19A1 Lentivirus particle
    ORF Viral VectorvGMAP000276Human CYP19A1 Adenovirus particle
    ORF Viral VectorpGMLPm003021mouse Cyp19a1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003021mouse Cyp19a1 Lentivirus particle


    Target information

    Target IDGM-T13260
    Target NameCYP19A1
    Gene ID1588,13075,25147,678697,494003,101094932,281740,100009712
    Gene Symbol and SynonymsAr,ArKO,ARO,ARO1,Aromatase,CPV1,CYAR,CYP19,Cyp19a,CYP19A1,CYP19P1,CYPXIX,Int-5,Int5,P-450AROM,p450arom
    Uniprot AccessionP11511,P22443,Q5QQX7,P46194,O46512
    Uniprot Entry NameCP19A_HUMAN,CP19A_RAT,CP19A_CANLF,CP19A_BOVIN,CP19A_HORSE
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseBreast cancer
    Gene EnsemblENSG00000137869
    Target ClassificationN/A

    The target: CYP19A1, gene name: CYP19A1, also named as ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.