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Anti-CA-I monoclonal antibody
Pre-made anti-CA-I monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CA-I/CA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13201-Ab-1/ GM-Tg-hg-T13201-Ab-2 | Anti-Human CA-I/CA1 monoclonal antibody | Human |
| GM-Tg-rg-T13201-Ab-1/ GM-Tg-rg-T13201-Ab-2 | Anti-Rat CA-I/CA1 monoclonal antibody | Rat |
| GM-Tg-mg-T13201-Ab-1/ GM-Tg-mg-T13201-Ab-2 | Anti-Mouse CA-I/CA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T13201-Ab-1/ GM-Tg-cynog-T13201-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CA-I/CA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13201-Ab-1/ GM-Tg-felg-T13201-Ab-2 | Anti-Feline CA-I/CA1 monoclonal antibody | Feline |
| GM-Tg-cang-T13201-Ab-1/ GM-Tg-cang-T13201-Ab-2 | Anti-Canine CA-I/CA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T13201-Ab-1/ GM-Tg-bovg-T13201-Ab-2 | Anti-Bovine CA-I/CA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T13201-Ab-1/ GM-Tg-equg-T13201-Ab-2 | Anti-Equine CA-I/CA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13201-Ab-1/ GM-Tg-hg-T13201-Ab-2; GM-Tg-rg-T13201-Ab-1/ GM-Tg-rg-T13201-Ab-2; GM-Tg-mg-T13201-Ab-1/ GM-Tg-mg-T13201-Ab-2; GM-Tg-cynog-T13201-Ab-1/ GM-Tg-cynog-T13201-Ab-2; GM-Tg-felg-T13201-Ab-1/ GM-Tg-felg-T13201-Ab-2; GM-Tg-cang-T13201-Ab-1/ GM-Tg-cang-T13201-Ab-2; GM-Tg-bovg-T13201-Ab-1/ GM-Tg-bovg-T13201-Ab-2; GM-Tg-equg-T13201-Ab-1/ GM-Tg-equg-T13201-Ab-2 |
| Products Name | Anti-CA-I/CA1 monoclonal antibody |
| Format | mab |
| Target Name | CA-I |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CA-I monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T13201-Ag-1 | Recombinant multi-species CAH1/ CA-I/ CA1 protein |
| ORF Viral Vector | vGMLP003029 | human CA1 Lentivirus particle |
| ORF Viral Vector | pGMLP003029 | human CA1 Lentivirus plasmid |
Target information
| Target ID | GM-T13201 |
| Target Name | CA-I |
| Gene ID | 759,12346,310218,703701,487031,101094399,100050192 |
| Gene Symbol and Synonyms | CA-I,CA1,CAB,Car-1,Car1,HEL-S-11 |
| Uniprot Accession | P00915,B0BNN3,P00916,P00917 |
| Uniprot Entry Name | CAH1_HUMAN,CAH1_MACMU,CAH1_RAT,CAH1_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Dent disease, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000133742 |
| Target Classification | N/A |
The target: CA-I, gene name: CA1, also named as CA-I, CAB, Car1, HEL-S-11. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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