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Anti-NET1/ NTN1/ NTN1L functional antibody
Anti-NET1/ NTN1/ NTN1L functional antibody for cell culture, ELISA & in-vivo assay
Go to NTN1/NTN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13086-Ab-1/ GM-Tg-hg-T13086-Ab-2 | Anti-Human NTN1 monoclonal antibody | Human |
| GM-Tg-rg-T13086-Ab-1/ GM-Tg-rg-T13086-Ab-2 | Anti-Rat NTN1 monoclonal antibody | Rat |
| GM-Tg-mg-T13086-Ab-1/ GM-Tg-mg-T13086-Ab-2 | Anti-Mouse NTN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T13086-Ab-1/ GM-Tg-cynog-T13086-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NTN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13086-Ab-1/ GM-Tg-felg-T13086-Ab-2 | Anti-Feline NTN1 monoclonal antibody | Feline |
| GM-Tg-cang-T13086-Ab-1/ GM-Tg-cang-T13086-Ab-2 | Anti-Canine NTN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T13086-Ab-1/ GM-Tg-bovg-T13086-Ab-2 | Anti-Bovine NTN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T13086-Ab-1/ GM-Tg-equg-T13086-Ab-2 | Anti-Equine NTN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13086-Ab-1/ GM-Tg-hg-T13086-Ab-2; GM-Tg-rg-T13086-Ab-1/ GM-Tg-rg-T13086-Ab-2; GM-Tg-mg-T13086-Ab-1/ GM-Tg-mg-T13086-Ab-2; GM-Tg-cynog-T13086-Ab-1/ GM-Tg-cynog-T13086-Ab-2; GM-Tg-felg-T13086-Ab-1/ GM-Tg-felg-T13086-Ab-2; GM-Tg-cang-T13086-Ab-1/ GM-Tg-cang-T13086-Ab-2; GM-Tg-bovg-T13086-Ab-1/ GM-Tg-bovg-T13086-Ab-2; GM-Tg-equg-T13086-Ab-1/ GM-Tg-equg-T13086-Ab-2 |
| Products Name | Anti-NTN1 monoclonal antibody |
| Format | mab |
| Target Name | NTN1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NTN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T13086-Ag-1 | Recombinant multi-species NET1/ NTN1/ NTN1L protein |
| ORF Viral Vector | pGMLP001539 | human NTN1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001539 | human NTN1 Lentivirus particle |
| ORF Viral Vector | pGMLV000845 | house mouse Ntn1 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000215 | mouse Ntn1 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000845 | house mouse Ntn1 Lentivirus particle |
| ORF Viral Vector | vGMAD000215 | mouse Ntn1 Adenovirus particle |
Target information
| Target ID | GM-T13086 |
| Target Name | NTN1 |
| Gene ID | 9423,18208,114523,717645,489497,101082606,522767,100073071 |
| Gene Symbol and Synonyms | MRMV4,NET1,Netrin-1,NTN1,NTN1L |
| Uniprot Accession | O95631,Q924Z9 |
| Uniprot Entry Name | NET1_HUMAN,NET1_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | prostate tumor, Acute kidney failure |
| Gene Ensembl | ENSG00000065320 |
| Target Classification | N/A |
The target: NTN1, gene name: NTN1, also named as NTN1L. Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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