Anti-PTPN11 monoclonal antibody

Pre-made anti-PTPN11 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PTPN11/PTPN11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2Anti-Human PTPN11 monoclonal antibodyHuman
GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2Anti-Rat PTPN11 monoclonal antibodyRat
GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2Anti-Mouse PTPN11 monoclonal antibodyMouse
GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2Anti-Cynomolgus/ Rhesus macaque PTPN11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2Anti-Feline PTPN11 monoclonal antibodyFeline
GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2Anti-Canine PTPN11 monoclonal antibodyCanine
GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2Anti-Bovine PTPN11 monoclonal antibodyBovine
GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2Anti-Equine PTPN11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T13057-Ab-1/ GM-Tg-hg-T13057-Ab-2; GM-Tg-rg-T13057-Ab-1/ GM-Tg-rg-T13057-Ab-2;
GM-Tg-mg-T13057-Ab-1/ GM-Tg-mg-T13057-Ab-2; GM-Tg-cynog-T13057-Ab-1/ GM-Tg-cynog-T13057-Ab-2;
GM-Tg-felg-T13057-Ab-1/ GM-Tg-felg-T13057-Ab-2; GM-Tg-cang-T13057-Ab-1/ GM-Tg-cang-T13057-Ab-2;
GM-Tg-bovg-T13057-Ab-1/ GM-Tg-bovg-T13057-Ab-2; GM-Tg-equg-T13057-Ab-1/ GM-Tg-equg-T13057-Ab-2
Products NameAnti-PTPN11 monoclonal antibody
Formatmab
Target NamePTPN11
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PTPN11 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T13057-Ag-1Recombinant multi-species PTN11/ PTPN11/ BPTP3 protein
    ORF Viral VectorpGMAD000149human PTPN11 Adenovirus plasmid
    ORF Viral VectorpGMLV000276human PTPN11 Lentivirus plasmid
    ORF Viral VectorvGMLV000276human PTPN11 Lentivirus particle
    ORF Viral VectorvGMAD000149human PTPN11 Adenovirus particle
    ORF Viral VectorpGMLV000403mouse Ptpn11 Lentivirus plasmid
    ORF Viral VectorvGMLV000403mouse Ptpn11 Lentivirus particle


    Target information

    Target IDGM-T13057
    Target NamePTPN11
    Gene ID5781,19247,25622,712044,477488,101085500,533590,100056857
    Gene Symbol and Synonyms2700084A17Rik,BPTP3,CFC,JMML,METCDS,NS1,PTP-1D,PTP1D,PTP2C,PTPN11,SAP-2,SH-PTP2,SH-PTP3,SHP-2,SHP2,Syp
    Uniprot AccessionQ06124,P41499
    Uniprot Entry NamePTN11_HUMAN,PTN11_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000179295
    Target ClassificationN/A

    The target: PTPN11, gene name: PTPN11, also named as BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.