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Anti-LCK monoclonal antibody
Pre-made anti-LCK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LCK/LCK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T12499-Ab-1/ GM-Tg-hg-T12499-Ab-2 | Anti-Human LCK monoclonal antibody | Human |
| GM-Tg-rg-T12499-Ab-1/ GM-Tg-rg-T12499-Ab-2 | Anti-Rat LCK monoclonal antibody | Rat |
| GM-Tg-mg-T12499-Ab-1/ GM-Tg-mg-T12499-Ab-2 | Anti-Mouse LCK monoclonal antibody | Mouse |
| GM-Tg-cynog-T12499-Ab-1/ GM-Tg-cynog-T12499-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LCK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T12499-Ab-1/ GM-Tg-felg-T12499-Ab-2 | Anti-Feline LCK monoclonal antibody | Feline |
| GM-Tg-cang-T12499-Ab-1/ GM-Tg-cang-T12499-Ab-2 | Anti-Canine LCK monoclonal antibody | Canine |
| GM-Tg-bovg-T12499-Ab-1/ GM-Tg-bovg-T12499-Ab-2 | Anti-Bovine LCK monoclonal antibody | Bovine |
| GM-Tg-equg-T12499-Ab-1/ GM-Tg-equg-T12499-Ab-2 | Anti-Equine LCK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T12499-Ab-1/ GM-Tg-hg-T12499-Ab-2; GM-Tg-rg-T12499-Ab-1/ GM-Tg-rg-T12499-Ab-2; GM-Tg-mg-T12499-Ab-1/ GM-Tg-mg-T12499-Ab-2; GM-Tg-cynog-T12499-Ab-1/ GM-Tg-cynog-T12499-Ab-2; GM-Tg-felg-T12499-Ab-1/ GM-Tg-felg-T12499-Ab-2; GM-Tg-cang-T12499-Ab-1/ GM-Tg-cang-T12499-Ab-2; GM-Tg-bovg-T12499-Ab-1/ GM-Tg-bovg-T12499-Ab-2; GM-Tg-equg-T12499-Ab-1/ GM-Tg-equg-T12499-Ab-2 |
| Products Name | Anti-LCK monoclonal antibody |
| Format | mab |
| Target Name | LCK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LCK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T12499-Ag-1 | Recombinant multi-species LCK/ IMD22/ LSK protein |
| ORF Viral Vector | pGMLPm005214 | mouse Lck Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005214 | mouse Lck Lentivirus particle |
Target information
| Target ID | GM-T12499 |
| Target Name | LCK |
| Gene ID | 3932,16818,313050,717704,478151,101098805,508890,100146139 |
| Gene Symbol and Synonyms | Hck-3,IMD22,LCK,Lck1,Lcktkr,LSK,Lskt,p56-LCK,p56 |
| Uniprot Accession | P06239,Q01621 |
| Uniprot Entry Name | LCK_HUMAN,LCK_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000182866 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: LCK, gene name: LCK, also named as IMD22, LSK, YT16, p56lck, pp58lck. This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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