Anti-CCND1 monoclonal antibody

Pre-made anti-CCND1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to CCND1/CCND1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T12355-Ab-1/ GM-Tg-hg-T12355-Ab-2Anti-Human CCND1 monoclonal antibodyHuman
GM-Tg-rg-T12355-Ab-1/ GM-Tg-rg-T12355-Ab-2Anti-Rat CCND1 monoclonal antibodyRat
GM-Tg-mg-T12355-Ab-1/ GM-Tg-mg-T12355-Ab-2Anti-Mouse CCND1 monoclonal antibodyMouse
GM-Tg-cynog-T12355-Ab-1/ GM-Tg-cynog-T12355-Ab-2Anti-Cynomolgus/ Rhesus macaque CCND1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T12355-Ab-1/ GM-Tg-felg-T12355-Ab-2Anti-Feline CCND1 monoclonal antibodyFeline
GM-Tg-cang-T12355-Ab-1/ GM-Tg-cang-T12355-Ab-2Anti-Canine CCND1 monoclonal antibodyCanine
GM-Tg-bovg-T12355-Ab-1/ GM-Tg-bovg-T12355-Ab-2Anti-Bovine CCND1 monoclonal antibodyBovine
GM-Tg-equg-T12355-Ab-1/ GM-Tg-equg-T12355-Ab-2Anti-Equine CCND1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T12355-Ab-1/ GM-Tg-hg-T12355-Ab-2; GM-Tg-rg-T12355-Ab-1/ GM-Tg-rg-T12355-Ab-2;
GM-Tg-mg-T12355-Ab-1/ GM-Tg-mg-T12355-Ab-2; GM-Tg-cynog-T12355-Ab-1/ GM-Tg-cynog-T12355-Ab-2;
GM-Tg-felg-T12355-Ab-1/ GM-Tg-felg-T12355-Ab-2; GM-Tg-cang-T12355-Ab-1/ GM-Tg-cang-T12355-Ab-2;
GM-Tg-bovg-T12355-Ab-1/ GM-Tg-bovg-T12355-Ab-2; GM-Tg-equg-T12355-Ab-1/ GM-Tg-equg-T12355-Ab-2
Products NameAnti-CCND1 monoclonal antibody
Formatmab
Target NameCCND1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-CCND1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T12355-Ag-1Recombinant multi-species CCND1/ BCL1/ D11S287E protein
    ORF Viral VectorvGMAP000562Human CCND1 Adenovirus particle
    ORF Viral VectorpGMLV000670human CCND1 Lentivirus plasmid
    ORF Viral VectorvGMLV000670human CCND1 Lentivirus particle
    ORF Viral VectorpGMLV000042human CCND1 Lentivirus plasmid
    ORF Viral VectorvGMLV000042human CCND1 Lentivirus particle
    ORF Viral VectorpGMAP000562Human CCND1 Adenovirus plasmid
    ORF Viral VectorpGMLPm003702mouse Ccnd1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003702mouse Ccnd1 Lentivirus particle


    Target information

    Target IDGM-T12355
    Target NameCCND1
    Gene ID595,12443,58919,574320,449028,100037407,524530,102149114
    Gene Symbol and Synonymsbcl-1,BCL1,CCND1,cD1,CycD1,Cyl-1,D11S287E,PRAD1,U21B31
    Uniprot AccessionP24385,P39948,Q64HP0,Q2KI22
    Uniprot Entry NameCCND1_HUMAN,CCND1_RAT,CCND1_CANLF,CCND1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseBreast Cancer, Head and neck squamous cell carcinoma (HNSCC), tumor, Cancer, Breast cancer
    Gene EnsemblENSG00000110092
    Target ClassificationN/A

    The target: CCND1, gene name: CCND1, also named as BCL1, D11S287E, PRAD1, U21B31. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.