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Anti-CTH monoclonal antibody
Pre-made anti-CTH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CTH/CTH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T12241-Ab-1/ GM-Tg-hg-T12241-Ab-2 | Anti-Human CTH monoclonal antibody | Human |
| GM-Tg-rg-T12241-Ab-1/ GM-Tg-rg-T12241-Ab-2 | Anti-Rat CTH monoclonal antibody | Rat |
| GM-Tg-mg-T12241-Ab-1/ GM-Tg-mg-T12241-Ab-2 | Anti-Mouse CTH monoclonal antibody | Mouse |
| GM-Tg-cynog-T12241-Ab-1/ GM-Tg-cynog-T12241-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T12241-Ab-1/ GM-Tg-felg-T12241-Ab-2 | Anti-Feline CTH monoclonal antibody | Feline |
| GM-Tg-cang-T12241-Ab-1/ GM-Tg-cang-T12241-Ab-2 | Anti-Canine CTH monoclonal antibody | Canine |
| GM-Tg-bovg-T12241-Ab-1/ GM-Tg-bovg-T12241-Ab-2 | Anti-Bovine CTH monoclonal antibody | Bovine |
| GM-Tg-equg-T12241-Ab-1/ GM-Tg-equg-T12241-Ab-2 | Anti-Equine CTH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T12241-Ab-1/ GM-Tg-hg-T12241-Ab-2; GM-Tg-rg-T12241-Ab-1/ GM-Tg-rg-T12241-Ab-2; GM-Tg-mg-T12241-Ab-1/ GM-Tg-mg-T12241-Ab-2; GM-Tg-cynog-T12241-Ab-1/ GM-Tg-cynog-T12241-Ab-2; GM-Tg-felg-T12241-Ab-1/ GM-Tg-felg-T12241-Ab-2; GM-Tg-cang-T12241-Ab-1/ GM-Tg-cang-T12241-Ab-2; GM-Tg-bovg-T12241-Ab-1/ GM-Tg-bovg-T12241-Ab-2; GM-Tg-equg-T12241-Ab-1/ GM-Tg-equg-T12241-Ab-2 |
| Products Name | Anti-CTH monoclonal antibody |
| Format | mab |
| Target Name | CTH |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CTH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T12241-Ag-1 | Recombinant multi-species CGL/ CTH protein |
| ORF Viral Vector | pGMLV000312 | human CTH Lentivirus plasmid |
| ORF Viral Vector | vGMLV000312 | human CTH Lentivirus particle |
| ORF Viral Vector | pGMLPm002075 | mouse Cth Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002075 | mouse Cth Lentivirus particle |
Target information
| Target ID | GM-T12241 |
| Target Name | CTH |
| Gene ID | 1491,107869,24962,696664,479991,101083282,539159,100053614 |
| Gene Symbol and Synonyms | 0610010I13Rik,CGL,CSE,CTH,Cys3 |
| Uniprot Accession | P32929,P18757,Q58DW2 |
| Uniprot Entry Name | CGL_HUMAN,CGL_RAT,CGL_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000116761 |
| Target Classification | N/A |
The target: CTH, gene name: CTH, also named as . This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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