- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-XCT/ SLC7A11/ CCBR1 monoclonal antibody
Anti-XCT/ SLC7A11/ CCBR1 antibody for FACS & in-vivo assay
Go to SLC7A11/SLC7A11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T11615-Ab-1/ GM-Tg-hg-T11615-Ab-2 | Anti-Human SLC7A11 monoclonal antibody | Human |
| GM-Tg-rg-T11615-Ab-1/ GM-Tg-rg-T11615-Ab-2 | Anti-Rat SLC7A11 monoclonal antibody | Rat |
| GM-Tg-mg-T11615-Ab-1/ GM-Tg-mg-T11615-Ab-2 | Anti-Mouse SLC7A11 monoclonal antibody | Mouse |
| GM-Tg-cynog-T11615-Ab-1/ GM-Tg-cynog-T11615-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC7A11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T11615-Ab-1/ GM-Tg-felg-T11615-Ab-2 | Anti-Feline SLC7A11 monoclonal antibody | Feline |
| GM-Tg-cang-T11615-Ab-1/ GM-Tg-cang-T11615-Ab-2 | Anti-Canine SLC7A11 monoclonal antibody | Canine |
| GM-Tg-bovg-T11615-Ab-1/ GM-Tg-bovg-T11615-Ab-2 | Anti-Bovine SLC7A11 monoclonal antibody | Bovine |
| GM-Tg-equg-T11615-Ab-1/ GM-Tg-equg-T11615-Ab-2 | Anti-Equine SLC7A11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T11615-Ab-1/ GM-Tg-hg-T11615-Ab-2; GM-Tg-rg-T11615-Ab-1/ GM-Tg-rg-T11615-Ab-2; GM-Tg-mg-T11615-Ab-1/ GM-Tg-mg-T11615-Ab-2; GM-Tg-cynog-T11615-Ab-1/ GM-Tg-cynog-T11615-Ab-2; GM-Tg-felg-T11615-Ab-1/ GM-Tg-felg-T11615-Ab-2; GM-Tg-cang-T11615-Ab-1/ GM-Tg-cang-T11615-Ab-2; GM-Tg-bovg-T11615-Ab-1/ GM-Tg-bovg-T11615-Ab-2; GM-Tg-equg-T11615-Ab-1/ GM-Tg-equg-T11615-Ab-2 |
| Products Name | Anti-SLC7A11 monoclonal antibody |
| Format | mab |
| Target Name | SLC7A11 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC7A11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species XCT/ SLC7A11/ CCBR1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000645 | human SLC7A11 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002698 | human SLC7A11 Lentivirus particle |
| ORF Viral Vector | pGMLP002698 | human SLC7A11 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000645 | human SLC7A11 Lentivirus particle |
| ORF Viral Vector | pGMLPm004468 | mouse Slc7a11 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004468 | mouse Slc7a11 Lentivirus particle |
Target information
| Target ID | GM-T11615 |
| Target Name | SLC7A11 |
| Gene ID | 23657,26570,310392,696516,483821,101099374,524078,100063433 |
| Gene Symbol and Synonyms | 9930009M05Rik,CCBR1,SLC7A11,sut,xCT |
| Uniprot Accession | Q9UPY5 |
| Uniprot Entry Name | XCT_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000151012 |
| Target Classification | N/A |
The target: SLC7A11, gene name: SLC7A11, also named as CCBR1, xCT. This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
