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Anti-CDK8 monoclonal antibody
Pre-made anti-CDK8 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CDK8/CDK8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T10822-Ab-1/ GM-Tg-hg-T10822-Ab-2 | Anti-Human CDK8 monoclonal antibody | Human |
| GM-Tg-rg-T10822-Ab-1/ GM-Tg-rg-T10822-Ab-2 | Anti-Rat CDK8 monoclonal antibody | Rat |
| GM-Tg-mg-T10822-Ab-1/ GM-Tg-mg-T10822-Ab-2 | Anti-Mouse CDK8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T10822-Ab-1/ GM-Tg-cynog-T10822-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDK8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T10822-Ab-1/ GM-Tg-felg-T10822-Ab-2 | Anti-Feline CDK8 monoclonal antibody | Feline |
| GM-Tg-cang-T10822-Ab-1/ GM-Tg-cang-T10822-Ab-2 | Anti-Canine CDK8 monoclonal antibody | Canine |
| GM-Tg-bovg-T10822-Ab-1/ GM-Tg-bovg-T10822-Ab-2 | Anti-Bovine CDK8 monoclonal antibody | Bovine |
| GM-Tg-equg-T10822-Ab-1/ GM-Tg-equg-T10822-Ab-2 | Anti-Equine CDK8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T10822-Ab-1/ GM-Tg-hg-T10822-Ab-2; GM-Tg-rg-T10822-Ab-1/ GM-Tg-rg-T10822-Ab-2; GM-Tg-mg-T10822-Ab-1/ GM-Tg-mg-T10822-Ab-2; GM-Tg-cynog-T10822-Ab-1/ GM-Tg-cynog-T10822-Ab-2; GM-Tg-felg-T10822-Ab-1/ GM-Tg-felg-T10822-Ab-2; GM-Tg-cang-T10822-Ab-1/ GM-Tg-cang-T10822-Ab-2; GM-Tg-bovg-T10822-Ab-1/ GM-Tg-bovg-T10822-Ab-2; GM-Tg-equg-T10822-Ab-1/ GM-Tg-equg-T10822-Ab-2 |
| Products Name | Anti-CDK8 monoclonal antibody |
| Format | mab |
| Target Name | CDK8 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CDK8 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T10822-Ag-1 | Recombinant multi-species CDK8/ K35 protein |
| ORF Viral Vector | vGMLV000486 | human CDK8 Lentivirus particle |
| ORF Viral Vector | pGMLV000486 | human CDK8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001388 | mouse Cdk8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001388 | mouse Cdk8 Lentivirus particle |
Target information
| Target ID | GM-T10822 |
| Target Name | CDK8 |
| Gene ID | 1024,264064,498140,709761,486035,101086278,507149,100050819 |
| Gene Symbol and Synonyms | CDK8,IDDHBA,K35,RGD1560888 |
| Uniprot Accession | P49336 |
| Uniprot Entry Name | CDK8_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000132964 |
| Target Classification | Kinase |
The target: CDK8, gene name: CDK8, also named as K35. This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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