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Anti-BMP6/ VGR/ VGR1 functional antibody
Anti-BMP6/ VGR/ VGR1 functional antibody for cell culture, ELISA & in-vivo assay
Go to BMP6/BMP6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T10762-Ab-1/ GM-Tg-hg-T10762-Ab-2 | Anti-Human BMP6 monoclonal antibody | Human |
| GM-Tg-rg-T10762-Ab-1/ GM-Tg-rg-T10762-Ab-2 | Anti-Rat BMP6 monoclonal antibody | Rat |
| GM-Tg-mg-T10762-Ab-1/ GM-Tg-mg-T10762-Ab-2 | Anti-Mouse BMP6 monoclonal antibody | Mouse |
| GM-Tg-cynog-T10762-Ab-1/ GM-Tg-cynog-T10762-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BMP6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T10762-Ab-1/ GM-Tg-felg-T10762-Ab-2 | Anti-Feline BMP6 monoclonal antibody | Feline |
| GM-Tg-cang-T10762-Ab-1/ GM-Tg-cang-T10762-Ab-2 | Anti-Canine BMP6 monoclonal antibody | Canine |
| GM-Tg-bovg-T10762-Ab-1/ GM-Tg-bovg-T10762-Ab-2 | Anti-Bovine BMP6 monoclonal antibody | Bovine |
| GM-Tg-equg-T10762-Ab-1/ GM-Tg-equg-T10762-Ab-2 | Anti-Equine BMP6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T10762-Ab-1/ GM-Tg-hg-T10762-Ab-2; GM-Tg-rg-T10762-Ab-1/ GM-Tg-rg-T10762-Ab-2; GM-Tg-mg-T10762-Ab-1/ GM-Tg-mg-T10762-Ab-2; GM-Tg-cynog-T10762-Ab-1/ GM-Tg-cynog-T10762-Ab-2; GM-Tg-felg-T10762-Ab-1/ GM-Tg-felg-T10762-Ab-2; GM-Tg-cang-T10762-Ab-1/ GM-Tg-cang-T10762-Ab-2; GM-Tg-bovg-T10762-Ab-1/ GM-Tg-bovg-T10762-Ab-2; GM-Tg-equg-T10762-Ab-1/ GM-Tg-equg-T10762-Ab-2 |
| Products Name | Anti-BMP6 monoclonal antibody |
| Format | mab |
| Target Name | BMP6 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BMP6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T10762-Ag-1 | Recombinant multi-species BMP6/ VGR/ VGR1 protein |
| Cytokine | GM-Tg-g-T10762-Ag-1 | bone morphogenetic protein 6 (BMP6) protein |
| ORF Viral Vector | vGMLP001608 | human BMP6 Lentivirus particle |
| ORF Viral Vector | pGMLP001608 | human BMP6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005224 | mouse Bmp6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005224 | mouse Bmp6 Lentivirus particle |
Target information
| Target ID | GM-T10762 |
| Target Name | BMP6 |
| Gene ID | 654,12161,25644,695091,478715,101098870,617566,100033934 |
| Gene Symbol and Synonyms | BMP6,D13Wsu115e,IO,VGR,VGR1 |
| Uniprot Accession | P22004,Q04906 |
| Uniprot Entry Name | BMP6_HUMAN,BMP6_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000153162 |
| Target Classification | N/A |
The target: BMP6, gene name: BMP6, also named as VGR, VGR1. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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