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Anti-SPRC/ SPARC/ BM-40 monoclonal antibody
Anti-SPRC/ SPARC/ BM-40 antibody for FACS & in-vivo assay
Go to SPARC/SPARC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09439-Ab-1/ GM-Tg-hg-T09439-Ab-2 | Anti-Human SPARC monoclonal antibody | Human |
| GM-Tg-rg-T09439-Ab-1/ GM-Tg-rg-T09439-Ab-2 | Anti-Rat SPARC monoclonal antibody | Rat |
| GM-Tg-mg-T09439-Ab-1/ GM-Tg-mg-T09439-Ab-2 | Anti-Mouse SPARC monoclonal antibody | Mouse |
| GM-Tg-cynog-T09439-Ab-1/ GM-Tg-cynog-T09439-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPARC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09439-Ab-1/ GM-Tg-felg-T09439-Ab-2 | Anti-Feline SPARC monoclonal antibody | Feline |
| GM-Tg-cang-T09439-Ab-1/ GM-Tg-cang-T09439-Ab-2 | Anti-Canine SPARC monoclonal antibody | Canine |
| GM-Tg-bovg-T09439-Ab-1/ GM-Tg-bovg-T09439-Ab-2 | Anti-Bovine SPARC monoclonal antibody | Bovine |
| GM-Tg-equg-T09439-Ab-1/ GM-Tg-equg-T09439-Ab-2 | Anti-Equine SPARC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09439-Ab-1/ GM-Tg-hg-T09439-Ab-2; GM-Tg-rg-T09439-Ab-1/ GM-Tg-rg-T09439-Ab-2; GM-Tg-mg-T09439-Ab-1/ GM-Tg-mg-T09439-Ab-2; GM-Tg-cynog-T09439-Ab-1/ GM-Tg-cynog-T09439-Ab-2; GM-Tg-felg-T09439-Ab-1/ GM-Tg-felg-T09439-Ab-2; GM-Tg-cang-T09439-Ab-1/ GM-Tg-cang-T09439-Ab-2; GM-Tg-bovg-T09439-Ab-1/ GM-Tg-bovg-T09439-Ab-2; GM-Tg-equg-T09439-Ab-1/ GM-Tg-equg-T09439-Ab-2 |
| Products Name | Anti-SPARC monoclonal antibody |
| Format | mab |
| Target Name | SPARC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPARC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SPRC/ SPARC/ BM-40 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000365 | Human SPARC Adenovirus plasmid |
| ORF Viral Vector | vGMLV000261 | human SPARC Lentivirus particle |
| ORF Viral Vector | vGMAP000365 | Human SPARC Adenovirus particle |
| ORF Viral Vector | pGMLV000261 | human SPARC Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001003 | mouse Sparc Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001004 | mouse Sparc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001003 | mouse Sparc Lentivirus particle |
| ORF Viral Vector | vGMLPm001004 | mouse Sparc Lentivirus particle |
Target information
| Target ID | GM-T09439 |
| Target Name | SPARC |
| Gene ID | 6678,20692,24791,712388,100855736,101099861,282077,100060119 |
| Gene Symbol and Synonyms | BM-40,OI17,ON,ONT,SPARC |
| Uniprot Accession | P09486,P16975,P13213 |
| Uniprot Entry Name | SPRC_HUMAN,SPRC_RAT,SPRC_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000113140 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SPARC, gene name: SPARC, also named as BM-40, OI17, ON. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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