Anti-SPRC/ SPARC/ BM-40 monoclonal antibody

Anti-SPRC/ SPARC/ BM-40 antibody for FACS & in-vivo assay

Target products collectionGo to SPARC/SPARC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T09439-Ab-1/ GM-Tg-hg-T09439-Ab-2Anti-Human SPARC monoclonal antibodyHuman
GM-Tg-rg-T09439-Ab-1/ GM-Tg-rg-T09439-Ab-2Anti-Rat SPARC monoclonal antibodyRat
GM-Tg-mg-T09439-Ab-1/ GM-Tg-mg-T09439-Ab-2Anti-Mouse SPARC monoclonal antibodyMouse
GM-Tg-cynog-T09439-Ab-1/ GM-Tg-cynog-T09439-Ab-2Anti-Cynomolgus/ Rhesus macaque SPARC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T09439-Ab-1/ GM-Tg-felg-T09439-Ab-2Anti-Feline SPARC monoclonal antibodyFeline
GM-Tg-cang-T09439-Ab-1/ GM-Tg-cang-T09439-Ab-2Anti-Canine SPARC monoclonal antibodyCanine
GM-Tg-bovg-T09439-Ab-1/ GM-Tg-bovg-T09439-Ab-2Anti-Bovine SPARC monoclonal antibodyBovine
GM-Tg-equg-T09439-Ab-1/ GM-Tg-equg-T09439-Ab-2Anti-Equine SPARC monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T09439-Ab-1/ GM-Tg-hg-T09439-Ab-2; GM-Tg-rg-T09439-Ab-1/ GM-Tg-rg-T09439-Ab-2;
GM-Tg-mg-T09439-Ab-1/ GM-Tg-mg-T09439-Ab-2; GM-Tg-cynog-T09439-Ab-1/ GM-Tg-cynog-T09439-Ab-2;
GM-Tg-felg-T09439-Ab-1/ GM-Tg-felg-T09439-Ab-2; GM-Tg-cang-T09439-Ab-1/ GM-Tg-cang-T09439-Ab-2;
GM-Tg-bovg-T09439-Ab-1/ GM-Tg-bovg-T09439-Ab-2; GM-Tg-equg-T09439-Ab-1/ GM-Tg-equg-T09439-Ab-2
Products NameAnti-SPARC monoclonal antibody
Formatmab
Target NameSPARC
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPARC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPRC/ SPARC/ BM-40 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAP000365Human SPARC Adenovirus plasmid
    ORF Viral VectorvGMLV000261human SPARC Lentivirus particle
    ORF Viral VectorvGMAP000365Human SPARC Adenovirus particle
    ORF Viral VectorpGMLV000261human SPARC Lentivirus plasmid
    ORF Viral VectorpGMLPm001003mouse Sparc Lentivirus plasmid
    ORF Viral VectorpGMLPm001004mouse Sparc Lentivirus plasmid
    ORF Viral VectorvGMLPm001003mouse Sparc Lentivirus particle
    ORF Viral VectorvGMLPm001004mouse Sparc Lentivirus particle


    Target information

    Target IDGM-T09439
    Target NameSPARC
    Gene ID6678,20692,24791,712388,100855736,101099861,282077,100060119
    Gene Symbol and SynonymsBM-40,OI17,ON,ONT,SPARC
    Uniprot AccessionP09486,P16975,P13213
    Uniprot Entry NameSPRC_HUMAN,SPRC_RAT,SPRC_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000113140
    Target ClassificationTumor-associated antigen (TAA)

    The target: SPARC, gene name: SPARC, also named as BM-40, OI17, ON. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.