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Anti-DDR1/ CAK/ CD167 monoclonal antibody
Anti-DDR1/ CAK/ CD167 antibody for FACS & in-vivo assay
Go to DDR1/DDR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09185-Ab-1/ GM-Tg-hg-T09185-Ab-2 | Anti-Human DDR1 monoclonal antibody | Human |
| GM-Tg-rg-T09185-Ab-1/ GM-Tg-rg-T09185-Ab-2 | Anti-Rat DDR1 monoclonal antibody | Rat |
| GM-Tg-mg-T09185-Ab-1/ GM-Tg-mg-T09185-Ab-2 | Anti-Mouse DDR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T09185-Ab-1/ GM-Tg-cynog-T09185-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DDR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09185-Ab-1/ GM-Tg-felg-T09185-Ab-2 | Anti-Feline DDR1 monoclonal antibody | Feline |
| GM-Tg-cang-T09185-Ab-1/ GM-Tg-cang-T09185-Ab-2 | Anti-Canine DDR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T09185-Ab-1/ GM-Tg-bovg-T09185-Ab-2 | Anti-Bovine DDR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T09185-Ab-1/ GM-Tg-equg-T09185-Ab-2 | Anti-Equine DDR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09185-Ab-1/ GM-Tg-hg-T09185-Ab-2; GM-Tg-rg-T09185-Ab-1/ GM-Tg-rg-T09185-Ab-2; GM-Tg-mg-T09185-Ab-1/ GM-Tg-mg-T09185-Ab-2; GM-Tg-cynog-T09185-Ab-1/ GM-Tg-cynog-T09185-Ab-2; GM-Tg-felg-T09185-Ab-1/ GM-Tg-felg-T09185-Ab-2; GM-Tg-cang-T09185-Ab-1/ GM-Tg-cang-T09185-Ab-2; GM-Tg-bovg-T09185-Ab-1/ GM-Tg-bovg-T09185-Ab-2; GM-Tg-equg-T09185-Ab-1/ GM-Tg-equg-T09185-Ab-2 |
| Products Name | Anti-DDR1 monoclonal antibody |
| Format | mab |
| Target Name | DDR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DDR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DDR1/ CAK/ CD167 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T09185 |
| Target Name | DDR1 |
| Gene ID | 780,12305,25678,714233,100856512,101096728,534092,100050861 |
| Gene Symbol and Synonyms | 6030432F18,CAK,CD167,CD167a,DDR,DDR1,Drd1,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,PTK3D,RTK6,TRKE |
| Uniprot Accession | Q08345,Q63474 |
| Uniprot Entry Name | DDR1_HUMAN,DDR1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000204580 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DDR1, gene name: DDR1, also named as CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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