Anti-DDR1/ CAK/ CD167 monoclonal antibody

Anti-DDR1/ CAK/ CD167 antibody for FACS & in-vivo assay

Target products collectionGo to DDR1/DDR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T09185-Ab-1/ GM-Tg-hg-T09185-Ab-2Anti-Human DDR1 monoclonal antibodyHuman
GM-Tg-rg-T09185-Ab-1/ GM-Tg-rg-T09185-Ab-2Anti-Rat DDR1 monoclonal antibodyRat
GM-Tg-mg-T09185-Ab-1/ GM-Tg-mg-T09185-Ab-2Anti-Mouse DDR1 monoclonal antibodyMouse
GM-Tg-cynog-T09185-Ab-1/ GM-Tg-cynog-T09185-Ab-2Anti-Cynomolgus/ Rhesus macaque DDR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T09185-Ab-1/ GM-Tg-felg-T09185-Ab-2Anti-Feline DDR1 monoclonal antibodyFeline
GM-Tg-cang-T09185-Ab-1/ GM-Tg-cang-T09185-Ab-2Anti-Canine DDR1 monoclonal antibodyCanine
GM-Tg-bovg-T09185-Ab-1/ GM-Tg-bovg-T09185-Ab-2Anti-Bovine DDR1 monoclonal antibodyBovine
GM-Tg-equg-T09185-Ab-1/ GM-Tg-equg-T09185-Ab-2Anti-Equine DDR1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T09185-Ab-1/ GM-Tg-hg-T09185-Ab-2; GM-Tg-rg-T09185-Ab-1/ GM-Tg-rg-T09185-Ab-2;
GM-Tg-mg-T09185-Ab-1/ GM-Tg-mg-T09185-Ab-2; GM-Tg-cynog-T09185-Ab-1/ GM-Tg-cynog-T09185-Ab-2;
GM-Tg-felg-T09185-Ab-1/ GM-Tg-felg-T09185-Ab-2; GM-Tg-cang-T09185-Ab-1/ GM-Tg-cang-T09185-Ab-2;
GM-Tg-bovg-T09185-Ab-1/ GM-Tg-bovg-T09185-Ab-2; GM-Tg-equg-T09185-Ab-1/ GM-Tg-equg-T09185-Ab-2
Products NameAnti-DDR1 monoclonal antibody
Formatmab
Target NameDDR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DDR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DDR1/ CAK/ CD167 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T09185
    Target NameDDR1
    Gene ID780,12305,25678,714233,100856512,101096728,534092,100050861
    Gene Symbol and Synonyms6030432F18,CAK,CD167,CD167a,DDR,DDR1,Drd1,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,PTK3D,RTK6,TRKE
    Uniprot AccessionQ08345,Q63474
    Uniprot Entry NameDDR1_HUMAN,DDR1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000204580
    Target ClassificationTumor-associated antigen (TAA)

    The target: DDR1, gene name: DDR1, also named as CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.