Anti-LIRB2/ LILRB2/ CD85D monoclonal antibody

Anti-LIRB2/ LILRB2/ CD85D antibody for FACS & in-vivo assay

Target products collectionGo to LILRB2/LILRB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T07931-Ab-1/ GM-Tg-hg-T07931-Ab-2Anti-Human LILRB2 monoclonal antibodyHuman
GM-Tg-rg-T07931-Ab-1/ GM-Tg-rg-T07931-Ab-2Anti-Rat LILRB2 monoclonal antibodyRat
GM-Tg-mg-T07931-Ab-1/ GM-Tg-mg-T07931-Ab-2Anti-Mouse LILRB2 monoclonal antibodyMouse
GM-Tg-cynog-T07931-Ab-1/ GM-Tg-cynog-T07931-Ab-2Anti-Cynomolgus/ Rhesus macaque LILRB2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T07931-Ab-1/ GM-Tg-felg-T07931-Ab-2Anti-Feline LILRB2 monoclonal antibodyFeline
GM-Tg-cang-T07931-Ab-1/ GM-Tg-cang-T07931-Ab-2Anti-Canine LILRB2 monoclonal antibodyCanine
GM-Tg-bovg-T07931-Ab-1/ GM-Tg-bovg-T07931-Ab-2Anti-Bovine LILRB2 monoclonal antibodyBovine
GM-Tg-equg-T07931-Ab-1/ GM-Tg-equg-T07931-Ab-2Anti-Equine LILRB2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T07931-Ab-1/ GM-Tg-hg-T07931-Ab-2; GM-Tg-rg-T07931-Ab-1/ GM-Tg-rg-T07931-Ab-2;
GM-Tg-mg-T07931-Ab-1/ GM-Tg-mg-T07931-Ab-2; GM-Tg-cynog-T07931-Ab-1/ GM-Tg-cynog-T07931-Ab-2;
GM-Tg-felg-T07931-Ab-1/ GM-Tg-felg-T07931-Ab-2; GM-Tg-cang-T07931-Ab-1/ GM-Tg-cang-T07931-Ab-2;
GM-Tg-bovg-T07931-Ab-1/ GM-Tg-bovg-T07931-Ab-2; GM-Tg-equg-T07931-Ab-1/ GM-Tg-equg-T07931-Ab-2
Products NameAnti-LILRB2 monoclonal antibody
Formatmab
Target NameLILRB2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LILRB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LIRB2/ LILRB2/ CD85D VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T07931
    Target NameLILRB2
    Gene ID10288
    Gene Symbol and SynonymsCD85D,ILT-4,ILT4,LILRB2,LIR-2,LIR2,MIR-10,MIR10
    Uniprot AccessionQ8N423
    Uniprot Entry NameLIRB2_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000131042
    Target ClassificationN/A

    The target: LILRB2, gene name: LILRB2, also named as CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.