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Anti-MYH7 monoclonal antibody
Pre-made anti-MYH7 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MYH7/MYH7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T07507-Ab-1/ GM-Tg-hg-T07507-Ab-2 | Anti-Human MYH7 monoclonal antibody | Human |
| GM-Tg-rg-T07507-Ab-1/ GM-Tg-rg-T07507-Ab-2 | Anti-Rat MYH7 monoclonal antibody | Rat |
| GM-Tg-mg-T07507-Ab-1/ GM-Tg-mg-T07507-Ab-2 | Anti-Mouse MYH7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T07507-Ab-1/ GM-Tg-cynog-T07507-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MYH7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T07507-Ab-1/ GM-Tg-felg-T07507-Ab-2 | Anti-Feline MYH7 monoclonal antibody | Feline |
| GM-Tg-cang-T07507-Ab-1/ GM-Tg-cang-T07507-Ab-2 | Anti-Canine MYH7 monoclonal antibody | Canine |
| GM-Tg-bovg-T07507-Ab-1/ GM-Tg-bovg-T07507-Ab-2 | Anti-Bovine MYH7 monoclonal antibody | Bovine |
| GM-Tg-equg-T07507-Ab-1/ GM-Tg-equg-T07507-Ab-2 | Anti-Equine MYH7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T07507-Ab-1/ GM-Tg-hg-T07507-Ab-2; GM-Tg-rg-T07507-Ab-1/ GM-Tg-rg-T07507-Ab-2; GM-Tg-mg-T07507-Ab-1/ GM-Tg-mg-T07507-Ab-2; GM-Tg-cynog-T07507-Ab-1/ GM-Tg-cynog-T07507-Ab-2; GM-Tg-felg-T07507-Ab-1/ GM-Tg-felg-T07507-Ab-2; GM-Tg-cang-T07507-Ab-1/ GM-Tg-cang-T07507-Ab-2; GM-Tg-bovg-T07507-Ab-1/ GM-Tg-bovg-T07507-Ab-2; GM-Tg-equg-T07507-Ab-1/ GM-Tg-equg-T07507-Ab-2 |
| Products Name | Anti-MYH7 monoclonal antibody |
| Format | mab |
| Target Name | MYH7 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MYH7 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T07507-Ag-1 | Recombinant multi-species MYH7/ CMD1S/ CMH1 protein |
Target information
| Target ID | GM-T07507 |
| Target Name | MYH7 |
| Gene ID | 4625,140781,403807,101096736,791234 |
| Gene Symbol and Synonyms | B-MHC,beta-MHC,betaMHC,CMD1S,CMH1,CMYP7A,CMYP7B,MPD1,MYH-beta/slow,MYH7,MyHC-alpha,Myhc-b,myHC-beta,MyHC-I,myHC-slow,MYHCB,MyHCS,SPMD,SPMM |
| Uniprot Accession | P12883,P49824,Q8MJU9 |
| Uniprot Entry Name | MYH7_HUMAN,MYH7_CANLF,MYH7_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Heart failure, Congenital occlusion of ureteropelvic junction |
| Gene Ensembl | ENSG00000092054 |
| Target Classification | N/A |
The target: MYH7, gene name: MYH7, also named as CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM. Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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