Anti-NOTC1/ NOTCH1/ AOS5 monoclonal antibody

Anti-NOTC1/ NOTCH1/ AOS5 antibody for FACS & in-vivo assay

Target products collectionGo to NOTCH1/NOTCH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T07394-Ab-1/ GM-Tg-hg-T07394-Ab-2Anti-Human NOTCH1 monoclonal antibodyHuman
GM-Tg-rg-T07394-Ab-1/ GM-Tg-rg-T07394-Ab-2Anti-Rat NOTCH1 monoclonal antibodyRat
GM-Tg-mg-T07394-Ab-1/ GM-Tg-mg-T07394-Ab-2Anti-Mouse NOTCH1 monoclonal antibodyMouse
GM-Tg-cynog-T07394-Ab-1/ GM-Tg-cynog-T07394-Ab-2Anti-Cynomolgus/ Rhesus macaque NOTCH1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T07394-Ab-1/ GM-Tg-felg-T07394-Ab-2Anti-Feline NOTCH1 monoclonal antibodyFeline
GM-Tg-cang-T07394-Ab-1/ GM-Tg-cang-T07394-Ab-2Anti-Canine NOTCH1 monoclonal antibodyCanine
GM-Tg-bovg-T07394-Ab-1/ GM-Tg-bovg-T07394-Ab-2Anti-Bovine NOTCH1 monoclonal antibodyBovine
GM-Tg-equg-T07394-Ab-1/ GM-Tg-equg-T07394-Ab-2Anti-Equine NOTCH1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T07394-Ab-1/ GM-Tg-hg-T07394-Ab-2; GM-Tg-rg-T07394-Ab-1/ GM-Tg-rg-T07394-Ab-2;
GM-Tg-mg-T07394-Ab-1/ GM-Tg-mg-T07394-Ab-2; GM-Tg-cynog-T07394-Ab-1/ GM-Tg-cynog-T07394-Ab-2;
GM-Tg-felg-T07394-Ab-1/ GM-Tg-felg-T07394-Ab-2; GM-Tg-cang-T07394-Ab-1/ GM-Tg-cang-T07394-Ab-2;
GM-Tg-bovg-T07394-Ab-1/ GM-Tg-bovg-T07394-Ab-2; GM-Tg-equg-T07394-Ab-1/ GM-Tg-equg-T07394-Ab-2
Products NameAnti-NOTCH1 monoclonal antibody
Formatmab
Target NameNOTCH1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NOTCH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-084Pre-Made Brontictuzumab biosimilar, Whole mAb, Anti-NOTCH1 Antibody: Anti-AOS5/AOVD1/TAN1/hN1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species NOTC1/ NOTCH1/ AOS5 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T07394-Ag-1Notch homolog 1 (NOTCH1) protein


    Target information

    Target IDGM-T07394
    Target NameNOTCH1
    Gene ID4851,18128,25496,709947,480676,101094384,767866,100068764
    Gene Symbol and Synonyms9930111A19Rik,AOS5,AOVD1,hN1,lin-12,Mis6,N1,N1ICD,NOTCH,NOTCH1,TAN1
    Uniprot AccessionP46531,Q07008
    Uniprot Entry NameNOTC1_HUMAN,NOTC1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000148400
    Target ClassificationTumor-associated antigen (TAA)

    The target: NOTCH1, gene name: NOTCH1, also named as AOS5, AOVD1, TAN1, hN1. This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.