Anti-IL18/ IGIF/ IL-18 functional antibody

Anti-IL18/ IGIF/ IL-18 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IL18/IL18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T06671-Ab-1/ GM-Tg-hg-T06671-Ab-2Anti-Human IL18 monoclonal antibodyHuman
GM-Tg-rg-T06671-Ab-1/ GM-Tg-rg-T06671-Ab-2Anti-Rat IL18 monoclonal antibodyRat
GM-Tg-mg-T06671-Ab-1/ GM-Tg-mg-T06671-Ab-2Anti-Mouse IL18 monoclonal antibodyMouse
GM-Tg-cynog-T06671-Ab-1/ GM-Tg-cynog-T06671-Ab-2Anti-Cynomolgus/ Rhesus macaque IL18 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T06671-Ab-1/ GM-Tg-felg-T06671-Ab-2Anti-Feline IL18 monoclonal antibodyFeline
GM-Tg-cang-T06671-Ab-1/ GM-Tg-cang-T06671-Ab-2Anti-Canine IL18 monoclonal antibodyCanine
GM-Tg-bovg-T06671-Ab-1/ GM-Tg-bovg-T06671-Ab-2Anti-Bovine IL18 monoclonal antibodyBovine
GM-Tg-equg-T06671-Ab-1/ GM-Tg-equg-T06671-Ab-2Anti-Equine IL18 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T06671-Ab-1/ GM-Tg-hg-T06671-Ab-2; GM-Tg-rg-T06671-Ab-1/ GM-Tg-rg-T06671-Ab-2;
GM-Tg-mg-T06671-Ab-1/ GM-Tg-mg-T06671-Ab-2; GM-Tg-cynog-T06671-Ab-1/ GM-Tg-cynog-T06671-Ab-2;
GM-Tg-felg-T06671-Ab-1/ GM-Tg-felg-T06671-Ab-2; GM-Tg-cang-T06671-Ab-1/ GM-Tg-cang-T06671-Ab-2;
GM-Tg-bovg-T06671-Ab-1/ GM-Tg-bovg-T06671-Ab-2; GM-Tg-equg-T06671-Ab-1/ GM-Tg-equg-T06671-Ab-2
Products NameAnti-IL18 monoclonal antibody
Formatmab
Target NameIL18
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T06671-Ag-1Recombinant multi-species IL18/ IGIF/ IL-18 protein
    CytokineGM-Tg-g-T06671-Ag-1interleukin 18 (IL18) protein
    ORF Viral VectorpGMLP002771human IL18 Lentivirus plasmid
    ORF Viral VectorvGMLP002771human IL18 Lentivirus particle
    ORF Viral VectorpGMLPm000116mouse Il18 Lentivirus plasmid
    ORF Viral VectorpGMLPm005397mouse Il18 Lentivirus plasmid
    ORF Viral VectorvGMLPm000116mouse Il18 Lentivirus particle
    ORF Viral VectorvGMLPm005397mouse Il18 Lentivirus particle


    Target information

    Target IDGM-T06671
    Target NameIL18
    Gene ID3606,16173,29197,574151,403796,493688,281249,100034216
    Gene Symbol and SynonymsIGIF,IL-1 gamma,IL-18,IL-1g,IL18,IL1F4
    Uniprot AccessionQ14116,P97636,Q9XSR0,Q95M33,Q9TU73,Q9XSQ7
    Uniprot Entry NameIL18_HUMAN,IL18_RAT,IL18_FELCA,IL18_CANLF,IL18_BOVIN,IL18_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseBreast Cancer, Acute kidney failure, Overweight
    Gene EnsemblENSG00000150782
    Target ClassificationN/A

    The target: IL18, gene name: IL18, also named as IGIF, IL-18, IL-1g, IL1F4. The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.