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Anti-PARP1 monoclonal antibody
Pre-made anti-PARP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PARP1/PARP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06273-Ab-1/ GM-Tg-hg-T06273-Ab-2 | Anti-Human PARP1 monoclonal antibody | Human |
| GM-Tg-rg-T06273-Ab-1/ GM-Tg-rg-T06273-Ab-2 | Anti-Rat PARP1 monoclonal antibody | Rat |
| GM-Tg-mg-T06273-Ab-1/ GM-Tg-mg-T06273-Ab-2 | Anti-Mouse PARP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T06273-Ab-1/ GM-Tg-cynog-T06273-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PARP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06273-Ab-1/ GM-Tg-felg-T06273-Ab-2 | Anti-Feline PARP1 monoclonal antibody | Feline |
| GM-Tg-cang-T06273-Ab-1/ GM-Tg-cang-T06273-Ab-2 | Anti-Canine PARP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T06273-Ab-1/ GM-Tg-bovg-T06273-Ab-2 | Anti-Bovine PARP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T06273-Ab-1/ GM-Tg-equg-T06273-Ab-2 | Anti-Equine PARP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06273-Ab-1/ GM-Tg-hg-T06273-Ab-2; GM-Tg-rg-T06273-Ab-1/ GM-Tg-rg-T06273-Ab-2; GM-Tg-mg-T06273-Ab-1/ GM-Tg-mg-T06273-Ab-2; GM-Tg-cynog-T06273-Ab-1/ GM-Tg-cynog-T06273-Ab-2; GM-Tg-felg-T06273-Ab-1/ GM-Tg-felg-T06273-Ab-2; GM-Tg-cang-T06273-Ab-1/ GM-Tg-cang-T06273-Ab-2; GM-Tg-bovg-T06273-Ab-1/ GM-Tg-bovg-T06273-Ab-2; GM-Tg-equg-T06273-Ab-1/ GM-Tg-equg-T06273-Ab-2 |
| Products Name | Anti-PARP1 monoclonal antibody |
| Format | mab |
| Target Name | PARP1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PARP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T06273-Ag-1 | Recombinant multi-species PARP1/ ADPRT/ ADPRT 1 protein |
| ORF Viral Vector | vGMAD000125 | human PARP1 Adenovirus particle |
| ORF Viral Vector | pGMAD000125 | human PARP1 Adenovirus plasmid |
Target information
| Target ID | GM-T06273 |
| Target Name | PARP1 |
| Gene ID | 142,11545,25591,698806,490385,101081434,286764,100058523 |
| Gene Symbol and Synonyms | 5830444G22Rik,Adprp,ADPRT,ADPRT 1,ADPRT1,ARTD1,msPARP,pADPRT-1,PARP,PARP-1,PARP1,PARS,Poly-PARP,PPOL,sPARP-1 |
| Uniprot Accession | P09874,P27008,P18493 |
| Uniprot Entry Name | PARP1_HUMAN,PARP1_RAT,PARP1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000143799 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PARP1, gene name: PARP1, also named as ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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