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Anti-TGM2/ TG2/ TG(C) monoclonal antibody
Anti-TGM2/ TG2/ TG(C) antibody for FACS & in-vivo assay
Go to TG2/TGM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T05387-Ab-1/ GM-Tg-hg-T05387-Ab-2 | Anti-Human TG2/TGM2 monoclonal antibody | Human |
| GM-Tg-rg-T05387-Ab-1/ GM-Tg-rg-T05387-Ab-2 | Anti-Rat TG2/TGM2 monoclonal antibody | Rat |
| GM-Tg-mg-T05387-Ab-1/ GM-Tg-mg-T05387-Ab-2 | Anti-Mouse TG2/TGM2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T05387-Ab-1/ GM-Tg-cynog-T05387-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TG2/TGM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T05387-Ab-1/ GM-Tg-felg-T05387-Ab-2 | Anti-Feline TG2/TGM2 monoclonal antibody | Feline |
| GM-Tg-cang-T05387-Ab-1/ GM-Tg-cang-T05387-Ab-2 | Anti-Canine TG2/TGM2 monoclonal antibody | Canine |
| GM-Tg-bovg-T05387-Ab-1/ GM-Tg-bovg-T05387-Ab-2 | Anti-Bovine TG2/TGM2 monoclonal antibody | Bovine |
| GM-Tg-equg-T05387-Ab-1/ GM-Tg-equg-T05387-Ab-2 | Anti-Equine TG2/TGM2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T05387-Ab-1/ GM-Tg-hg-T05387-Ab-2; GM-Tg-rg-T05387-Ab-1/ GM-Tg-rg-T05387-Ab-2; GM-Tg-mg-T05387-Ab-1/ GM-Tg-mg-T05387-Ab-2; GM-Tg-cynog-T05387-Ab-1/ GM-Tg-cynog-T05387-Ab-2; GM-Tg-felg-T05387-Ab-1/ GM-Tg-felg-T05387-Ab-2; GM-Tg-cang-T05387-Ab-1/ GM-Tg-cang-T05387-Ab-2; GM-Tg-bovg-T05387-Ab-1/ GM-Tg-bovg-T05387-Ab-2; GM-Tg-equg-T05387-Ab-1/ GM-Tg-equg-T05387-Ab-2 |
| Products Name | Anti-TG2/TGM2 monoclonal antibody |
| Format | mab |
| Target Name | TG2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-638 | Pre-Made Zampilimab biosimilar, Whole mAb, Anti-TGM2/TG2 Antibody: Anti-G(h)/TG(C)/TGC/hTG2/tTG therapeutic antibody |
| Target Antigen | Products Developing | Multi-species TGM2/ TG2/ TG(C) VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000683 | human TGM2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000683 | human TGM2 Lentivirus particle |
Target information
| Target ID | GM-T05387 |
| Target Name | TG2 |
| Gene ID | 7052,21817,56083,706777,485867,101098215,281528,100070046 |
| Gene Symbol and Synonyms | G(h),G[a]h,hTG2,TG,TG(C),TG2,TGase2,TgaseII,TGC,TGM2,tTG,tTGas |
| Uniprot Accession | P21980,Q9WVJ6,P51176 |
| Uniprot Entry Name | TGM2_HUMAN,TGM2_RAT,TGM2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000198959 |
| Target Classification | N/A |
The target: TG2, gene name: TGM2, also named as TG(C), TGC. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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