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Anti-ACHA/ CHRNA1/ ACHRA monoclonal antibody
Anti-ACHA/ CHRNA1/ ACHRA antibody for FACS & in-vivo assay
Go to CHRNA1/CHRNA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T04689-Ab-1/ GM-Tg-hg-T04689-Ab-2 | Anti-Human CHRNA1 monoclonal antibody | Human |
| GM-Tg-rg-T04689-Ab-1/ GM-Tg-rg-T04689-Ab-2 | Anti-Rat CHRNA1 monoclonal antibody | Rat |
| GM-Tg-mg-T04689-Ab-1/ GM-Tg-mg-T04689-Ab-2 | Anti-Mouse CHRNA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T04689-Ab-1/ GM-Tg-cynog-T04689-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T04689-Ab-1/ GM-Tg-felg-T04689-Ab-2 | Anti-Feline CHRNA1 monoclonal antibody | Feline |
| GM-Tg-cang-T04689-Ab-1/ GM-Tg-cang-T04689-Ab-2 | Anti-Canine CHRNA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T04689-Ab-1/ GM-Tg-bovg-T04689-Ab-2 | Anti-Bovine CHRNA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T04689-Ab-1/ GM-Tg-equg-T04689-Ab-2 | Anti-Equine CHRNA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T04689-Ab-1/ GM-Tg-hg-T04689-Ab-2; GM-Tg-rg-T04689-Ab-1/ GM-Tg-rg-T04689-Ab-2; GM-Tg-mg-T04689-Ab-1/ GM-Tg-mg-T04689-Ab-2; GM-Tg-cynog-T04689-Ab-1/ GM-Tg-cynog-T04689-Ab-2; GM-Tg-felg-T04689-Ab-1/ GM-Tg-felg-T04689-Ab-2; GM-Tg-cang-T04689-Ab-1/ GM-Tg-cang-T04689-Ab-2; GM-Tg-bovg-T04689-Ab-1/ GM-Tg-bovg-T04689-Ab-2; GM-Tg-equg-T04689-Ab-1/ GM-Tg-equg-T04689-Ab-2 |
| Products Name | Anti-CHRNA1 monoclonal antibody |
| Format | mab |
| Target Name | CHRNA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHA/ CHRNA1/ ACHRA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003161 | human CHRNA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000421 | human CHRNA1 Lentivirus particle |
| ORF Viral Vector | vGMLP003161 | human CHRNA1 Lentivirus particle |
| ORF Viral Vector | pGMLV000421 | human CHRNA1 Lentivirus plasmid |
Target information
| Target ID | GM-T04689 |
| Target Name | CHRNA1 |
| Gene ID | 1134,11435,79557,698578,403757,751106,338070,100065034 |
| Gene Symbol and Synonyms | ACHR,Achr-1,ACHRA,ACHRD,Acra,CHRNA,CHRNA1,CMS1A,CMS1B,CMS2A,FCCMS,SCCMS |
| Uniprot Accession | P02708,P25108,P54250,P02709 |
| Uniprot Entry Name | ACHA_HUMAN,ACHA_RAT,ACHA_FELCA,ACHA_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000138435 |
| Target Classification | Ion Channel |
The target: CHRNA1, gene name: CHRNA1, also named as ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS. The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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