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Anti-IL1AP/ IL1RAP/ C3orf13 monoclonal antibody
Anti-IL1AP/ IL1RAP/ C3orf13 antibody for FACS & in-vivo assay
Go to IL1RAP/IL1RAP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02974-Ab-1/ GM-Tg-hg-T02974-Ab-2 | Anti-Human IL1RAP monoclonal antibody | Human |
| GM-Tg-rg-T02974-Ab-1/ GM-Tg-rg-T02974-Ab-2 | Anti-Rat IL1RAP monoclonal antibody | Rat |
| GM-Tg-mg-T02974-Ab-1/ GM-Tg-mg-T02974-Ab-2 | Anti-Mouse IL1RAP monoclonal antibody | Mouse |
| GM-Tg-cynog-T02974-Ab-1/ GM-Tg-cynog-T02974-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL1RAP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02974-Ab-1/ GM-Tg-felg-T02974-Ab-2 | Anti-Feline IL1RAP monoclonal antibody | Feline |
| GM-Tg-cang-T02974-Ab-1/ GM-Tg-cang-T02974-Ab-2 | Anti-Canine IL1RAP monoclonal antibody | Canine |
| GM-Tg-bovg-T02974-Ab-1/ GM-Tg-bovg-T02974-Ab-2 | Anti-Bovine IL1RAP monoclonal antibody | Bovine |
| GM-Tg-equg-T02974-Ab-1/ GM-Tg-equg-T02974-Ab-2 | Anti-Equine IL1RAP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02974-Ab-1/ GM-Tg-hg-T02974-Ab-2; GM-Tg-rg-T02974-Ab-1/ GM-Tg-rg-T02974-Ab-2; GM-Tg-mg-T02974-Ab-1/ GM-Tg-mg-T02974-Ab-2; GM-Tg-cynog-T02974-Ab-1/ GM-Tg-cynog-T02974-Ab-2; GM-Tg-felg-T02974-Ab-1/ GM-Tg-felg-T02974-Ab-2; GM-Tg-cang-T02974-Ab-1/ GM-Tg-cang-T02974-Ab-2; GM-Tg-bovg-T02974-Ab-1/ GM-Tg-bovg-T02974-Ab-2; GM-Tg-equg-T02974-Ab-1/ GM-Tg-equg-T02974-Ab-2 |
| Products Name | Anti-IL1RAP monoclonal antibody |
| Format | mab |
| Target Name | IL1RAP |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL1RAP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-375 | Pre-Made Nidanilimab biosimilar, Whole mAb, Anti-IL1RAP Antibody: Anti-C3orf13/IL-1RAcP/IL1R3 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species IL1AP/ IL1RAP/ C3orf13 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T02974-Ag-1 | interleukin 1 receptor accessory protein (IL1RAP) protein |
Target information
| Target ID | GM-T02974 |
| Target Name | IL1RAP |
| Gene ID | 3556,16180,25466,574387,488126,101094125,539334,100068726 |
| Gene Symbol and Synonyms | 6430709H04Rik,C3orf13,IL-1RAcP,IL1R3,Il1racpb,IL1RAP |
| Uniprot Accession | Q9NPH3,Q63621,P59822 |
| Uniprot Entry Name | IL1AP_HUMAN,IL1AP_MACMU,IL1AP_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000196083 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL1RAP, gene name: IL1RAP, also named as C3orf13, IL-1RAcP, IL1R3. This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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