Anti-IFNB/ IFNB1/ IFB functional antibody

Anti-IFNB/ IFNB1/ IFB functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IFNB1/IFNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T02808-Ab-1/ GM-Tg-hg-T02808-Ab-2Anti-Human IFNB1 monoclonal antibodyHuman
GM-Tg-rg-T02808-Ab-1/ GM-Tg-rg-T02808-Ab-2Anti-Rat IFNB1 monoclonal antibodyRat
GM-Tg-mg-T02808-Ab-1/ GM-Tg-mg-T02808-Ab-2Anti-Mouse IFNB1 monoclonal antibodyMouse
GM-Tg-cynog-T02808-Ab-1/ GM-Tg-cynog-T02808-Ab-2Anti-Cynomolgus/ Rhesus macaque IFNB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T02808-Ab-1/ GM-Tg-felg-T02808-Ab-2Anti-Feline IFNB1 monoclonal antibodyFeline
GM-Tg-cang-T02808-Ab-1/ GM-Tg-cang-T02808-Ab-2Anti-Canine IFNB1 monoclonal antibodyCanine
GM-Tg-bovg-T02808-Ab-1/ GM-Tg-bovg-T02808-Ab-2Anti-Bovine IFNB1 monoclonal antibodyBovine
GM-Tg-equg-T02808-Ab-1/ GM-Tg-equg-T02808-Ab-2Anti-Equine IFNB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T02808-Ab-1/ GM-Tg-hg-T02808-Ab-2; GM-Tg-rg-T02808-Ab-1/ GM-Tg-rg-T02808-Ab-2;
GM-Tg-mg-T02808-Ab-1/ GM-Tg-mg-T02808-Ab-2; GM-Tg-cynog-T02808-Ab-1/ GM-Tg-cynog-T02808-Ab-2;
GM-Tg-felg-T02808-Ab-1/ GM-Tg-felg-T02808-Ab-2; GM-Tg-cang-T02808-Ab-1/ GM-Tg-cang-T02808-Ab-2;
GM-Tg-bovg-T02808-Ab-1/ GM-Tg-bovg-T02808-Ab-2; GM-Tg-equg-T02808-Ab-1/ GM-Tg-equg-T02808-Ab-2
Products NameAnti-IFNB1 monoclonal antibody
Formatmab
Target NameIFNB1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IFNB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T02808-Ag-1Recombinant multi-species IFNB/ IFNB1/ IFB protein
    CytokineGM-Tg-g-T02808-Ag-1interferon, beta 1, fibroblast (IFNB1) protein
    ORF Viral VectorpGMAP000549Human IFNB1 Adenovirus plasmid
    ORF Viral VectorpGMLP000557human IFNB1 Lentivirus plasmid
    ORF Viral VectorvGMAP000549Human IFNB1 Adenovirus particle
    ORF Viral VectorvGMLP000557human IFNB1 Lentivirus particle
    ORF Viral VectorpGMLPm000109mouse Ifnb1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000109mouse Ifnb1 Lentivirus particle


    Target information

    Target IDGM-T02808
    Target NameIFNB1
    Gene ID3456,15977,24481,711414,481558,493849
    Gene Symbol and SynonymsIf1da1,IFB,IFF,IFN-beta,IFNB,IFNB1
    Uniprot AccessionP01574,P70499,Q9N2J0
    Uniprot Entry NameIFNB_HUMAN,IFNB_RAT,IFNB_FELCA
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000171855
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IFNB1, gene name: IFNB1, also named as IFB, IFF, IFN-beta, IFNB. This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.