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Anti-CCR3/ CC-CKR-3/ CD193 monoclonal antibody
Anti-CCR3/ CC-CKR-3/ CD193 antibody for FACS & in-vivo assay
Go to CCR3/CCR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02752-Ab-1/ GM-Tg-hg-T02752-Ab-2 | Anti-Human CCR3 monoclonal antibody | Human |
| GM-Tg-rg-T02752-Ab-1/ GM-Tg-rg-T02752-Ab-2 | Anti-Rat CCR3 monoclonal antibody | Rat |
| GM-Tg-mg-T02752-Ab-1/ GM-Tg-mg-T02752-Ab-2 | Anti-Mouse CCR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T02752-Ab-1/ GM-Tg-cynog-T02752-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02752-Ab-1/ GM-Tg-felg-T02752-Ab-2 | Anti-Feline CCR3 monoclonal antibody | Feline |
| GM-Tg-cang-T02752-Ab-1/ GM-Tg-cang-T02752-Ab-2 | Anti-Canine CCR3 monoclonal antibody | Canine |
| GM-Tg-bovg-T02752-Ab-1/ GM-Tg-bovg-T02752-Ab-2 | Anti-Bovine CCR3 monoclonal antibody | Bovine |
| GM-Tg-equg-T02752-Ab-1/ GM-Tg-equg-T02752-Ab-2 | Anti-Equine CCR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02752-Ab-1/ GM-Tg-hg-T02752-Ab-2; GM-Tg-rg-T02752-Ab-1/ GM-Tg-rg-T02752-Ab-2; GM-Tg-mg-T02752-Ab-1/ GM-Tg-mg-T02752-Ab-2; GM-Tg-cynog-T02752-Ab-1/ GM-Tg-cynog-T02752-Ab-2; GM-Tg-felg-T02752-Ab-1/ GM-Tg-felg-T02752-Ab-2; GM-Tg-cang-T02752-Ab-1/ GM-Tg-cang-T02752-Ab-2; GM-Tg-bovg-T02752-Ab-1/ GM-Tg-bovg-T02752-Ab-2; GM-Tg-equg-T02752-Ab-1/ GM-Tg-equg-T02752-Ab-2 |
| Products Name | Anti-CCR3 monoclonal antibody |
| Format | mab |
| Target Name | CCR3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR3/ CC-CKR-3/ CD193 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T02752-Ag-1 | chemokine (C-C motif) receptor 3 (CCR3) protein |
| ORF Viral Vector | pGMLPm002782 | mouse Ccr3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002782 | mouse Ccr3 Lentivirus particle |
Target information
| Target ID | GM-T02752 |
| Target Name | CCR3 |
| Gene ID | 1232,12771,117027,713368,448802,100191005,408018,100065437 |
| Gene Symbol and Synonyms | C C CKR3,CC-CKR-3,CC-CKR3,CCR3,CD193,CKR 3,CKR3,Cmkbr1l2,CMKBR3 |
| Uniprot Accession | P51677,O54814,P56483,Q64H34 |
| Uniprot Entry Name | CCR3_HUMAN,CCR3_MACMU,CCR3_RAT,CCR3_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000183625 |
| Target Classification | GPCR |
The target: CCR3, gene name: CCR3, also named as CC-CKR-3, CD193, CKR3, CMKBR3. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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