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Anti-CSF1R/ CSF-1R/ C-FMS monoclonal antibody
Anti-CSF1R/ CSF-1R/ C-FMS antibody for FACS & in-vivo assay
Go to CSF-1R/CSF1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T01110-Ab-1/ GM-Tg-hg-T01110-Ab-2 | Anti-Human CSF-1R/CSF1R monoclonal antibody | Human |
| GM-Tg-rg-T01110-Ab-1/ GM-Tg-rg-T01110-Ab-2 | Anti-Rat CSF-1R/CSF1R monoclonal antibody | Rat |
| GM-Tg-mg-T01110-Ab-1/ GM-Tg-mg-T01110-Ab-2 | Anti-Mouse CSF-1R/CSF1R monoclonal antibody | Mouse |
| GM-Tg-cynog-T01110-Ab-1/ GM-Tg-cynog-T01110-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CSF-1R/CSF1R monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T01110-Ab-1/ GM-Tg-felg-T01110-Ab-2 | Anti-Feline CSF-1R/CSF1R monoclonal antibody | Feline |
| GM-Tg-cang-T01110-Ab-1/ GM-Tg-cang-T01110-Ab-2 | Anti-Canine CSF-1R/CSF1R monoclonal antibody | Canine |
| GM-Tg-bovg-T01110-Ab-1/ GM-Tg-bovg-T01110-Ab-2 | Anti-Bovine CSF-1R/CSF1R monoclonal antibody | Bovine |
| GM-Tg-equg-T01110-Ab-1/ GM-Tg-equg-T01110-Ab-2 | Anti-Equine CSF-1R/CSF1R monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T01110-Ab-1/ GM-Tg-hg-T01110-Ab-2; GM-Tg-rg-T01110-Ab-1/ GM-Tg-rg-T01110-Ab-2; GM-Tg-mg-T01110-Ab-1/ GM-Tg-mg-T01110-Ab-2; GM-Tg-cynog-T01110-Ab-1/ GM-Tg-cynog-T01110-Ab-2; GM-Tg-felg-T01110-Ab-1/ GM-Tg-felg-T01110-Ab-2; GM-Tg-cang-T01110-Ab-1/ GM-Tg-cang-T01110-Ab-2; GM-Tg-bovg-T01110-Ab-1/ GM-Tg-bovg-T01110-Ab-2; GM-Tg-equg-T01110-Ab-1/ GM-Tg-equg-T01110-Ab-2 |
| Products Name | Anti-CSF-1R/CSF1R monoclonal antibody |
| Format | mab |
| Target Name | CSF-1R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CSF-1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CSF1R/ CSF-1R/ C-FMS VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T01110 |
| Target Name | CSF-1R |
| Gene ID | 1436,12978,307403,711512,489188,493706,509418,100060422 |
| Gene Symbol and Synonyms | BANDDOS,C-FMS,CD115,CSF-1-R,CSF-1R,CSF1,CSF1R,Csfmr,CSFR,Fim-2,FIM2,FMS,GPSC,HDLS,HDLS1,M-CSF,M-CSF-R,M-CSFR,mrfms |
| Uniprot Accession | P07333,Q00495,P13369 |
| Uniprot Entry Name | CSF1R_HUMAN,CSF1R_RAT,CSF1R_FELCA |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000182578 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: CSF-1R, gene name: CSF1R, also named as C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R. The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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