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Anti-CXCR1/ C-C/ C-C-CKR-1 monoclonal antibody
Anti-CXCR1/ C-C/ C-C-CKR-1 antibody for FACS & in-vivo assay
Go to CXCR1/CXCR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00884-Ab-1/ GM-Tg-hg-T00884-Ab-2 | Anti-Human CXCR1 monoclonal antibody | Human |
| GM-Tg-rg-T00884-Ab-1/ GM-Tg-rg-T00884-Ab-2 | Anti-Rat CXCR1 monoclonal antibody | Rat |
| GM-Tg-mg-T00884-Ab-1/ GM-Tg-mg-T00884-Ab-2 | Anti-Mouse CXCR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T00884-Ab-1/ GM-Tg-cynog-T00884-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00884-Ab-1/ GM-Tg-felg-T00884-Ab-2 | Anti-Feline CXCR1 monoclonal antibody | Feline |
| GM-Tg-cang-T00884-Ab-1/ GM-Tg-cang-T00884-Ab-2 | Anti-Canine CXCR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T00884-Ab-1/ GM-Tg-bovg-T00884-Ab-2 | Anti-Bovine CXCR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T00884-Ab-1/ GM-Tg-equg-T00884-Ab-2 | Anti-Equine CXCR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00884-Ab-1/ GM-Tg-hg-T00884-Ab-2; GM-Tg-rg-T00884-Ab-1/ GM-Tg-rg-T00884-Ab-2; GM-Tg-mg-T00884-Ab-1/ GM-Tg-mg-T00884-Ab-2; GM-Tg-cynog-T00884-Ab-1/ GM-Tg-cynog-T00884-Ab-2; GM-Tg-felg-T00884-Ab-1/ GM-Tg-felg-T00884-Ab-2; GM-Tg-cang-T00884-Ab-1/ GM-Tg-cang-T00884-Ab-2; GM-Tg-bovg-T00884-Ab-1/ GM-Tg-bovg-T00884-Ab-2; GM-Tg-equg-T00884-Ab-1/ GM-Tg-equg-T00884-Ab-2 |
| Products Name | Anti-CXCR1 monoclonal antibody |
| Format | mab |
| Target Name | CXCR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CXCR1/ C-C/ C-C-CKR-1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T00884-Ag-1 | chemokine (C-X-C motif) receptor 1 (CXCR1) protein |
Target information
| Target ID | GM-T00884 |
| Target Name | CXCR1 |
| Gene ID | 3577,692074 |
| Gene Symbol and Synonyms | C-C,C-C-CKR-1,CD128,CD181,CDw128a,CKR-1,CMKAR1,CXCR1,IL8R1,IL8RA,IL8RBA |
| Uniprot Accession | P25024,Q2YEG0 |
| Uniprot Entry Name | CXCR1_HUMAN,CXCR1_MACMU |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000163464 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: CXCR1, gene name: CXCR1, also named as C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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