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Anti-5-LOX monoclonal antibody
Pre-made anti-5-LOX monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to 5-LOX/ALOX5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00140-Ab-1/ GM-Tg-hg-T00140-Ab-2 | Anti-Human 5-LOX/ALOX5 monoclonal antibody | Human |
| GM-Tg-rg-T00140-Ab-1/ GM-Tg-rg-T00140-Ab-2 | Anti-Rat 5-LOX/ALOX5 monoclonal antibody | Rat |
| GM-Tg-mg-T00140-Ab-1/ GM-Tg-mg-T00140-Ab-2 | Anti-Mouse 5-LOX/ALOX5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T00140-Ab-1/ GM-Tg-cynog-T00140-Ab-2 | Anti-Cynomolgus/ Rhesus macaque 5-LOX/ALOX5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00140-Ab-1/ GM-Tg-felg-T00140-Ab-2 | Anti-Feline 5-LOX/ALOX5 monoclonal antibody | Feline |
| GM-Tg-cang-T00140-Ab-1/ GM-Tg-cang-T00140-Ab-2 | Anti-Canine 5-LOX/ALOX5 monoclonal antibody | Canine |
| GM-Tg-bovg-T00140-Ab-1/ GM-Tg-bovg-T00140-Ab-2 | Anti-Bovine 5-LOX/ALOX5 monoclonal antibody | Bovine |
| GM-Tg-equg-T00140-Ab-1/ GM-Tg-equg-T00140-Ab-2 | Anti-Equine 5-LOX/ALOX5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00140-Ab-1/ GM-Tg-hg-T00140-Ab-2; GM-Tg-rg-T00140-Ab-1/ GM-Tg-rg-T00140-Ab-2; GM-Tg-mg-T00140-Ab-1/ GM-Tg-mg-T00140-Ab-2; GM-Tg-cynog-T00140-Ab-1/ GM-Tg-cynog-T00140-Ab-2; GM-Tg-felg-T00140-Ab-1/ GM-Tg-felg-T00140-Ab-2; GM-Tg-cang-T00140-Ab-1/ GM-Tg-cang-T00140-Ab-2; GM-Tg-bovg-T00140-Ab-1/ GM-Tg-bovg-T00140-Ab-2; GM-Tg-equg-T00140-Ab-1/ GM-Tg-equg-T00140-Ab-2 |
| Products Name | Anti-5-LOX/ALOX5 monoclonal antibody |
| Format | mab |
| Target Name | 5-LOX |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-5-LOX monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T00140-Ag-1 | Recombinant multi-species LOX5/ 5-LOX/ ALOX5 protein |
| ORF Viral Vector | vGMAP000506 | Human ALOX5 Adenovirus particle |
| ORF Viral Vector | pGMAP000506 | Human ALOX5 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000885 | house mouse Alox5 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000885 | house mouse Alox5 Lentivirus particle |
Target information
| Target ID | GM-T00140 |
| Target Name | 5-LOX |
| Gene ID | 240,11689,25290,707926,477753,101097422,404074,100062042 |
| Gene Symbol and Synonyms | 5-LO,5-LOX,5LO,5LPG,5LX,ALOX5,F730011J02,LOG5,LOX5A |
| Uniprot Accession | P09917,P12527 |
| Uniprot Entry Name | LOX5_HUMAN,LOX5_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000012779 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: 5-LOX, gene name: ALOX5, also named as 5-LO, 5-LOX, 5LPG, LOG5. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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