Anti-S™P1/ C7orf73/ PL-5283 functional antibody

Anti-S™P1/ C7orf73/ PL-5283 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to S™P1/S™P1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1666-Ab-1/ GM-Tg-hg-SE1666-Ab-2Anti-Human S™P1 monoclonal antibodyHuman
GM-Tg-rg-SE1666-Ab-1/ GM-Tg-rg-SE1666-Ab-2Anti-Rat S™P1 monoclonal antibodyRat
GM-Tg-mg-SE1666-Ab-1/ GM-Tg-mg-SE1666-Ab-2Anti-Mouse S™P1 monoclonal antibodyMouse
GM-Tg-cynog-SE1666-Ab-1/ GM-Tg-cynog-SE1666-Ab-2Anti-Cynomolgus/ Rhesus macaque S™P1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1666-Ab-1/ GM-Tg-felg-SE1666-Ab-2Anti-Feline S™P1 monoclonal antibodyFeline
GM-Tg-cang-SE1666-Ab-1/ GM-Tg-cang-SE1666-Ab-2Anti-Canine S™P1 monoclonal antibodyCanine
GM-Tg-bovg-SE1666-Ab-1/ GM-Tg-bovg-SE1666-Ab-2Anti-Bovine S™P1 monoclonal antibodyBovine
GM-Tg-equg-SE1666-Ab-1/ GM-Tg-equg-SE1666-Ab-2Anti-Equine S™P1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1666-Ab-1/ GM-Tg-hg-SE1666-Ab-2; GM-Tg-rg-SE1666-Ab-1/ GM-Tg-rg-SE1666-Ab-2;
GM-Tg-mg-SE1666-Ab-1/ GM-Tg-mg-SE1666-Ab-2; GM-Tg-cynog-SE1666-Ab-1/ GM-Tg-cynog-SE1666-Ab-2;
GM-Tg-felg-SE1666-Ab-1/ GM-Tg-felg-SE1666-Ab-2; GM-Tg-cang-SE1666-Ab-1/ GM-Tg-cang-SE1666-Ab-2;
GM-Tg-bovg-SE1666-Ab-1/ GM-Tg-bovg-SE1666-Ab-2; GM-Tg-equg-SE1666-Ab-1/ GM-Tg-equg-SE1666-Ab-2
Products NameAnti-S™P1 monoclonal antibody
Formatmab
Target NameS™P1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-S™P1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1666-Ag-1Recombinant multi-species S™P1/ C7orf73/ PL-5283 protein


    Target information

    Target IDGM-SE1666
    Target NameS™P1
    Gene ID647087,67705,689574,610249,101099110,784845,100630834
    Gene Symbol and Synonyms1810058I24Rik,C16H7orf73,C4H7orf73,C7orf73,CA2H7orf73,Mm47,PL-5283,S™P1
    Uniprot AccessionE0CX11
    Uniprot Entry NameS™P1_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000243317
    Target ClassificationN/A

    The target: S™P1, gene name: S™P1, also named as C7orf73, PL-5283. Predicted to be involved in positive regulation of NLRP3 inflammasome complex assembly and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrial intermembrane space and mitochondrial outer membrane. Predicted to be active in mitochondrial respirasome. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.