Anti-DB112/ DEFB112/ DEFB-12 functional antibody

Anti-DB112/ DEFB112/ DEFB-12 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to DEFB112/DEFB112 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1627-Ab-1/ GM-Tg-hg-SE1627-Ab-2Anti-Human DEFB112 monoclonal antibodyHuman
GM-Tg-rg-SE1627-Ab-1/ GM-Tg-rg-SE1627-Ab-2Anti-Rat DEFB112 monoclonal antibodyRat
GM-Tg-mg-SE1627-Ab-1/ GM-Tg-mg-SE1627-Ab-2Anti-Mouse DEFB112 monoclonal antibodyMouse
GM-Tg-cynog-SE1627-Ab-1/ GM-Tg-cynog-SE1627-Ab-2Anti-Cynomolgus/ Rhesus macaque DEFB112 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1627-Ab-1/ GM-Tg-felg-SE1627-Ab-2Anti-Feline DEFB112 monoclonal antibodyFeline
GM-Tg-cang-SE1627-Ab-1/ GM-Tg-cang-SE1627-Ab-2Anti-Canine DEFB112 monoclonal antibodyCanine
GM-Tg-bovg-SE1627-Ab-1/ GM-Tg-bovg-SE1627-Ab-2Anti-Bovine DEFB112 monoclonal antibodyBovine
GM-Tg-equg-SE1627-Ab-1/ GM-Tg-equg-SE1627-Ab-2Anti-Equine DEFB112 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1627-Ab-1/ GM-Tg-hg-SE1627-Ab-2; GM-Tg-rg-SE1627-Ab-1/ GM-Tg-rg-SE1627-Ab-2;
GM-Tg-mg-SE1627-Ab-1/ GM-Tg-mg-SE1627-Ab-2; GM-Tg-cynog-SE1627-Ab-1/ GM-Tg-cynog-SE1627-Ab-2;
GM-Tg-felg-SE1627-Ab-1/ GM-Tg-felg-SE1627-Ab-2; GM-Tg-cang-SE1627-Ab-1/ GM-Tg-cang-SE1627-Ab-2;
GM-Tg-bovg-SE1627-Ab-1/ GM-Tg-bovg-SE1627-Ab-2; GM-Tg-equg-SE1627-Ab-1/ GM-Tg-equg-SE1627-Ab-2
Products NameAnti-DEFB112 monoclonal antibody
Formatmab
Target NameDEFB112
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DEFB112 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1627-Ag-1Recombinant multi-species DB112/ DEFB112/ DEFB-12 protein


    Target information

    Target IDGM-SE1627
    Target NameDEFB112
    Gene ID245915,106997956,101906162
    Gene Symbol and SynonymsDEFB-12,DEFB112
    Uniprot AccessionQ30KQ8
    Uniprot Entry NameDB112_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000180872
    Target ClassificationN/A

    The target: DEFB112, gene name: DEFB112, also named as DEFB-12. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.