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Anti-PDIA3/ ER60/ ERp57 functional antibody
Anti-PDIA3/ ER60/ ERp57 functional antibody for cell culture, ELISA & in-vivo assay
Go to PDIA3/PDIA3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1578-Ab-1/ GM-Tg-hg-SE1578-Ab-2 | Anti-Human PDIA3 monoclonal antibody | Human |
| GM-Tg-rg-SE1578-Ab-1/ GM-Tg-rg-SE1578-Ab-2 | Anti-Rat PDIA3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1578-Ab-1/ GM-Tg-mg-SE1578-Ab-2 | Anti-Mouse PDIA3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1578-Ab-1/ GM-Tg-cynog-SE1578-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDIA3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1578-Ab-1/ GM-Tg-felg-SE1578-Ab-2 | Anti-Feline PDIA3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1578-Ab-1/ GM-Tg-cang-SE1578-Ab-2 | Anti-Canine PDIA3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1578-Ab-1/ GM-Tg-bovg-SE1578-Ab-2 | Anti-Bovine PDIA3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1578-Ab-1/ GM-Tg-equg-SE1578-Ab-2 | Anti-Equine PDIA3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1578-Ab-1/ GM-Tg-hg-SE1578-Ab-2; GM-Tg-rg-SE1578-Ab-1/ GM-Tg-rg-SE1578-Ab-2; GM-Tg-mg-SE1578-Ab-1/ GM-Tg-mg-SE1578-Ab-2; GM-Tg-cynog-SE1578-Ab-1/ GM-Tg-cynog-SE1578-Ab-2; GM-Tg-felg-SE1578-Ab-1/ GM-Tg-felg-SE1578-Ab-2; GM-Tg-cang-SE1578-Ab-1/ GM-Tg-cang-SE1578-Ab-2; GM-Tg-bovg-SE1578-Ab-1/ GM-Tg-bovg-SE1578-Ab-2; GM-Tg-equg-SE1578-Ab-1/ GM-Tg-equg-SE1578-Ab-2 |
| Products Name | Anti-PDIA3 monoclonal antibody |
| Format | mab |
| Target Name | PDIA3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDIA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1578-Ag-1 | Recombinant multi-species PDIA3/ ER60/ ERp57 protein |
| ORF Viral Vector | vGMLP001897 | human PDIA3 Lentivirus particle |
| ORF Viral Vector | pGMLP001897 | human PDIA3 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000655 | Norway rat Pdia3 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000203 | mouse Pdia3 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000571 | house mouse Pdia3 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000655 | Norway rat Pdia3 Lentivirus particle |
| ORF Viral Vector | vGMAD000203 | mouse Pdia3 Adenovirus particle |
| ORF Viral Vector | vGMAD000571 | house mouse Pdia3 Adenovirus particle |
Target information
| Target ID | GM-SE1578 |
| Target Name | PDIA3 |
| Gene ID | 2923,14827,29468,711029,478279,101097245,281803,100056198 |
| Gene Symbol and Synonyms | 58kDa,ER60,Erp,ERp57,ERp60,ERp61,GRP57,GRP58,HEL-S-269,HEL-S-93n,HsT17083,P58,PDI,PDI-Q2,PDIA3,PI-PLC,Plca,PLC[a] |
| Uniprot Accession | P30101,P11598,P38657 |
| Uniprot Entry Name | PDIA3_HUMAN,PDIA3_RAT,PDIA3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000167004 |
| Target Classification | N/A |
The target: PDIA3, gene name: PDIA3, also named as ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC. This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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