Anti-PDIA3/ ER60/ ERp57 functional antibody

Anti-PDIA3/ ER60/ ERp57 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PDIA3/PDIA3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1578-Ab-1/ GM-Tg-hg-SE1578-Ab-2Anti-Human PDIA3 monoclonal antibodyHuman
GM-Tg-rg-SE1578-Ab-1/ GM-Tg-rg-SE1578-Ab-2Anti-Rat PDIA3 monoclonal antibodyRat
GM-Tg-mg-SE1578-Ab-1/ GM-Tg-mg-SE1578-Ab-2Anti-Mouse PDIA3 monoclonal antibodyMouse
GM-Tg-cynog-SE1578-Ab-1/ GM-Tg-cynog-SE1578-Ab-2Anti-Cynomolgus/ Rhesus macaque PDIA3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1578-Ab-1/ GM-Tg-felg-SE1578-Ab-2Anti-Feline PDIA3 monoclonal antibodyFeline
GM-Tg-cang-SE1578-Ab-1/ GM-Tg-cang-SE1578-Ab-2Anti-Canine PDIA3 monoclonal antibodyCanine
GM-Tg-bovg-SE1578-Ab-1/ GM-Tg-bovg-SE1578-Ab-2Anti-Bovine PDIA3 monoclonal antibodyBovine
GM-Tg-equg-SE1578-Ab-1/ GM-Tg-equg-SE1578-Ab-2Anti-Equine PDIA3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1578-Ab-1/ GM-Tg-hg-SE1578-Ab-2; GM-Tg-rg-SE1578-Ab-1/ GM-Tg-rg-SE1578-Ab-2;
GM-Tg-mg-SE1578-Ab-1/ GM-Tg-mg-SE1578-Ab-2; GM-Tg-cynog-SE1578-Ab-1/ GM-Tg-cynog-SE1578-Ab-2;
GM-Tg-felg-SE1578-Ab-1/ GM-Tg-felg-SE1578-Ab-2; GM-Tg-cang-SE1578-Ab-1/ GM-Tg-cang-SE1578-Ab-2;
GM-Tg-bovg-SE1578-Ab-1/ GM-Tg-bovg-SE1578-Ab-2; GM-Tg-equg-SE1578-Ab-1/ GM-Tg-equg-SE1578-Ab-2
Products NameAnti-PDIA3 monoclonal antibody
Formatmab
Target NamePDIA3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PDIA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1578-Ag-1Recombinant multi-species PDIA3/ ER60/ ERp57 protein
    ORF Viral VectorvGMLP001897human PDIA3 Lentivirus particle
    ORF Viral VectorpGMLP001897human PDIA3 Lentivirus plasmid
    ORF Viral VectorpGMLV000655Norway rat Pdia3 Lentivirus plasmid
    ORF Viral VectorpGMAD000203mouse Pdia3 Adenovirus plasmid
    ORF Viral VectorpGMAD000571house mouse Pdia3 Adenovirus plasmid
    ORF Viral VectorvGMLV000655Norway rat Pdia3 Lentivirus particle
    ORF Viral VectorvGMAD000203mouse Pdia3 Adenovirus particle
    ORF Viral VectorvGMAD000571house mouse Pdia3 Adenovirus particle


    Target information

    Target IDGM-SE1578
    Target NamePDIA3
    Gene ID2923,14827,29468,711029,478279,101097245,281803,100056198
    Gene Symbol and Synonyms58kDa,ER60,Erp,ERp57,ERp60,ERp61,GRP57,GRP58,HEL-S-269,HEL-S-93n,HsT17083,P58,PDI,PDI-Q2,PDIA3,PI-PLC,Plca,PLC[a]
    Uniprot AccessionP30101,P11598,P38657
    Uniprot Entry NamePDIA3_HUMAN,PDIA3_RAT,PDIA3_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000167004
    Target ClassificationN/A

    The target: PDIA3, gene name: PDIA3, also named as ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC. This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.