Anti-NAGS/ AGAS/ ARGA functional antibody

Anti-NAGS/ AGAS/ ARGA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NAGS/NAGS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1552-Ab-1/ GM-Tg-hg-SE1552-Ab-2Anti-Human NAGS monoclonal antibodyHuman
GM-Tg-rg-SE1552-Ab-1/ GM-Tg-rg-SE1552-Ab-2Anti-Rat NAGS monoclonal antibodyRat
GM-Tg-mg-SE1552-Ab-1/ GM-Tg-mg-SE1552-Ab-2Anti-Mouse NAGS monoclonal antibodyMouse
GM-Tg-cynog-SE1552-Ab-1/ GM-Tg-cynog-SE1552-Ab-2Anti-Cynomolgus/ Rhesus macaque NAGS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1552-Ab-1/ GM-Tg-felg-SE1552-Ab-2Anti-Feline NAGS monoclonal antibodyFeline
GM-Tg-cang-SE1552-Ab-1/ GM-Tg-cang-SE1552-Ab-2Anti-Canine NAGS monoclonal antibodyCanine
GM-Tg-bovg-SE1552-Ab-1/ GM-Tg-bovg-SE1552-Ab-2Anti-Bovine NAGS monoclonal antibodyBovine
GM-Tg-equg-SE1552-Ab-1/ GM-Tg-equg-SE1552-Ab-2Anti-Equine NAGS monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1552-Ab-1/ GM-Tg-hg-SE1552-Ab-2; GM-Tg-rg-SE1552-Ab-1/ GM-Tg-rg-SE1552-Ab-2;
GM-Tg-mg-SE1552-Ab-1/ GM-Tg-mg-SE1552-Ab-2; GM-Tg-cynog-SE1552-Ab-1/ GM-Tg-cynog-SE1552-Ab-2;
GM-Tg-felg-SE1552-Ab-1/ GM-Tg-felg-SE1552-Ab-2; GM-Tg-cang-SE1552-Ab-1/ GM-Tg-cang-SE1552-Ab-2;
GM-Tg-bovg-SE1552-Ab-1/ GM-Tg-bovg-SE1552-Ab-2; GM-Tg-equg-SE1552-Ab-1/ GM-Tg-equg-SE1552-Ab-2
Products NameAnti-NAGS monoclonal antibody
Formatmab
Target NameNAGS
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NAGS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1552-Ag-1Recombinant multi-species NAGS/ AGAS/ ARGA protein


    Target information

    Target IDGM-SE1552
    Target NameNAGS
    Gene ID162417,217214,303563,714102,490943,101097029,538004,100051467
    Gene Symbol and Synonyms1700120E20Rik,AGAS,ARGA,NAGS,RGD1565783
    Uniprot AccessionQ8N159
    Uniprot Entry NameNAGS_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000161653
    Target ClassificationN/A

    The target: NAGS, gene name: NAGS, also named as AGAS, ARGA. The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.