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Anti-VPRE3/ VPREB3/ 8HS20 functional antibody
Anti-VPRE3/ VPREB3/ 8HS20 functional antibody for cell culture, ELISA & in-vivo assay
Go to VPREB3/VPREB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1488-Ab-1/ GM-Tg-hg-SE1488-Ab-2 | Anti-Human VPREB3 monoclonal antibody | Human |
| GM-Tg-rg-SE1488-Ab-1/ GM-Tg-rg-SE1488-Ab-2 | Anti-Rat VPREB3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1488-Ab-1/ GM-Tg-mg-SE1488-Ab-2 | Anti-Mouse VPREB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1488-Ab-1/ GM-Tg-cynog-SE1488-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VPREB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1488-Ab-1/ GM-Tg-felg-SE1488-Ab-2 | Anti-Feline VPREB3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1488-Ab-1/ GM-Tg-cang-SE1488-Ab-2 | Anti-Canine VPREB3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1488-Ab-1/ GM-Tg-bovg-SE1488-Ab-2 | Anti-Bovine VPREB3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1488-Ab-1/ GM-Tg-equg-SE1488-Ab-2 | Anti-Equine VPREB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1488-Ab-1/ GM-Tg-hg-SE1488-Ab-2; GM-Tg-rg-SE1488-Ab-1/ GM-Tg-rg-SE1488-Ab-2; GM-Tg-mg-SE1488-Ab-1/ GM-Tg-mg-SE1488-Ab-2; GM-Tg-cynog-SE1488-Ab-1/ GM-Tg-cynog-SE1488-Ab-2; GM-Tg-felg-SE1488-Ab-1/ GM-Tg-felg-SE1488-Ab-2; GM-Tg-cang-SE1488-Ab-1/ GM-Tg-cang-SE1488-Ab-2; GM-Tg-bovg-SE1488-Ab-1/ GM-Tg-bovg-SE1488-Ab-2; GM-Tg-equg-SE1488-Ab-1/ GM-Tg-equg-SE1488-Ab-2 |
| Products Name | Anti-VPREB3 monoclonal antibody |
| Format | mab |
| Target Name | VPREB3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-VPREB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1488-Ag-1 | Recombinant multi-species VPRE3/ VPREB3/ 8HS20 protein |
Target information
| Target ID | GM-SE1488 |
| Target Name | VPREB3 |
| Gene ID | 29802,22364,365550,107000599,100683248,101092056,615795,100056657 |
| Gene Symbol and Synonyms | 8HS-20,8HS20,N27C7-2,Vpreb-3,VPREB3 |
| Uniprot Accession | Q9UKI3 |
| Uniprot Entry Name | VPRE3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000128218 |
| Target Classification | N/A |
The target: VPREB3, gene name: VPREB3, also named as 8HS20, N27C7-2. The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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