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Anti-GLIS3/ NDH/ ZNF515 functional antibody
Anti-GLIS3/ NDH/ ZNF515 functional antibody for cell culture, ELISA & in-vivo assay
Go to GLIS3/GLIS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1453-Ab-1/ GM-Tg-hg-SE1453-Ab-2 | Anti-Human GLIS3 monoclonal antibody | Human |
| GM-Tg-rg-SE1453-Ab-1/ GM-Tg-rg-SE1453-Ab-2 | Anti-Rat GLIS3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1453-Ab-1/ GM-Tg-mg-SE1453-Ab-2 | Anti-Mouse GLIS3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1453-Ab-1/ GM-Tg-cynog-SE1453-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GLIS3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1453-Ab-1/ GM-Tg-felg-SE1453-Ab-2 | Anti-Feline GLIS3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1453-Ab-1/ GM-Tg-cang-SE1453-Ab-2 | Anti-Canine GLIS3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1453-Ab-1/ GM-Tg-bovg-SE1453-Ab-2 | Anti-Bovine GLIS3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1453-Ab-1/ GM-Tg-equg-SE1453-Ab-2 | Anti-Equine GLIS3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1453-Ab-1/ GM-Tg-hg-SE1453-Ab-2; GM-Tg-rg-SE1453-Ab-1/ GM-Tg-rg-SE1453-Ab-2; GM-Tg-mg-SE1453-Ab-1/ GM-Tg-mg-SE1453-Ab-2; GM-Tg-cynog-SE1453-Ab-1/ GM-Tg-cynog-SE1453-Ab-2; GM-Tg-felg-SE1453-Ab-1/ GM-Tg-felg-SE1453-Ab-2; GM-Tg-cang-SE1453-Ab-1/ GM-Tg-cang-SE1453-Ab-2; GM-Tg-bovg-SE1453-Ab-1/ GM-Tg-bovg-SE1453-Ab-2; GM-Tg-equg-SE1453-Ab-1/ GM-Tg-equg-SE1453-Ab-2 |
| Products Name | Anti-GLIS3 monoclonal antibody |
| Format | mab |
| Target Name | GLIS3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GLIS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1453-Ag-1 | Recombinant multi-species GLIS3/ NDH/ ZNF515 protein |
Target information
| Target ID | GM-SE1453 |
| Target Name | GLIS3 |
| Gene ID | 169792,226075,680671,694900,484179,101100094,524909,100051202 |
| Gene Symbol and Synonyms | 4833409N03Rik,E330013K21Rik,GLIS3,NDH,RGD1565505,ZNF515 |
| Uniprot Accession | Q8NEA6 |
| Uniprot Entry Name | GLIS3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000107249 |
| Target Classification | N/A |
The target: GLIS3, gene name: GLIS3, also named as NDH, ZNF515. This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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