Anti-ATG5/ APG5/ APG5-LIKE functional antibody

Anti-ATG5/ APG5/ APG5-LIKE functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ATG5/ATG5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1410-Ab-1/ GM-Tg-hg-SE1410-Ab-2Anti-Human ATG5 monoclonal antibodyHuman
GM-Tg-rg-SE1410-Ab-1/ GM-Tg-rg-SE1410-Ab-2Anti-Rat ATG5 monoclonal antibodyRat
GM-Tg-mg-SE1410-Ab-1/ GM-Tg-mg-SE1410-Ab-2Anti-Mouse ATG5 monoclonal antibodyMouse
GM-Tg-cynog-SE1410-Ab-1/ GM-Tg-cynog-SE1410-Ab-2Anti-Cynomolgus/ Rhesus macaque ATG5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1410-Ab-1/ GM-Tg-felg-SE1410-Ab-2Anti-Feline ATG5 monoclonal antibodyFeline
GM-Tg-cang-SE1410-Ab-1/ GM-Tg-cang-SE1410-Ab-2Anti-Canine ATG5 monoclonal antibodyCanine
GM-Tg-bovg-SE1410-Ab-1/ GM-Tg-bovg-SE1410-Ab-2Anti-Bovine ATG5 monoclonal antibodyBovine
GM-Tg-equg-SE1410-Ab-1/ GM-Tg-equg-SE1410-Ab-2Anti-Equine ATG5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1410-Ab-1/ GM-Tg-hg-SE1410-Ab-2; GM-Tg-rg-SE1410-Ab-1/ GM-Tg-rg-SE1410-Ab-2;
GM-Tg-mg-SE1410-Ab-1/ GM-Tg-mg-SE1410-Ab-2; GM-Tg-cynog-SE1410-Ab-1/ GM-Tg-cynog-SE1410-Ab-2;
GM-Tg-felg-SE1410-Ab-1/ GM-Tg-felg-SE1410-Ab-2; GM-Tg-cang-SE1410-Ab-1/ GM-Tg-cang-SE1410-Ab-2;
GM-Tg-bovg-SE1410-Ab-1/ GM-Tg-bovg-SE1410-Ab-2; GM-Tg-equg-SE1410-Ab-1/ GM-Tg-equg-SE1410-Ab-2
Products NameAnti-ATG5 monoclonal antibody
Formatmab
Target NameATG5
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATG5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1410-Ag-1Recombinant multi-species ATG5/ APG5/ APG5-LIKE protein
    ORF Viral VectorvGMLV000230human ATG5 Lentivirus particle
    ORF Viral VectorpGMLV000230human ATG5 Lentivirus plasmid
    ORF Viral VectorpGMLV000506human ATG5 Lentivirus plasmid
    ORF Viral VectorvGMLV000506human ATG5 Lentivirus particle
    ORF Viral VectorpGMAD000032rat Atg5 Adenovirus plasmid
    ORF Viral VectorpGMAD000421Norway rat Atg5 Adenovirus plasmid
    ORF Viral VectorpGMAD000598house mouse Atg5 Adenovirus plasmid
    ORF Viral VectorpGMLPm000310mouse Atg5 Lentivirus plasmid
    ORF Viral VectorvGMAD000032rat Atg5 Adenovirus particle
    ORF Viral VectorvGMAD000421Norway rat Atg5 Adenovirus particle
    ORF Viral VectorvGMAD000598house mouse Atg5 Adenovirus particle
    ORF Viral VectorvGMLPm000310mouse Atg5 Lentivirus particle


    Target information

    Target IDGM-SE1410
    Target NameATG5
    Gene ID9474,11793,365601,696874,610868,101092114,532686,100066344
    Gene Symbol and Synonyms2010107M05Rik,3110067M24Rik,APG5,APG5-LIKE,APG5L,ASP,ATG5,Atg5l,hAPG5,Paddy,SCAR25
    Uniprot AccessionQ9H1Y0,Q3MQ06,Q3MQ24
    Uniprot Entry NameATG5_HUMAN,ATG5_RAT,ATG5_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseCancer
    Gene EnsemblENSG00000057663
    Target ClassificationTumor-associated antigen (TAA)

    The target: ATG5, gene name: ATG5, also named as APG5, APG5-LIKE, APG5L, ASP, SCAR25, hAPG5. The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.