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Anti-WN10B/ WNT10B/ SHFM6 functional antibody
Anti-WN10B/ WNT10B/ SHFM6 functional antibody for cell culture, ELISA & in-vivo assay
Go to WNT10B/WNT10B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1382-Ab-1/ GM-Tg-hg-SE1382-Ab-2 | Anti-Human WNT10B monoclonal antibody | Human |
| GM-Tg-rg-SE1382-Ab-1/ GM-Tg-rg-SE1382-Ab-2 | Anti-Rat WNT10B monoclonal antibody | Rat |
| GM-Tg-mg-SE1382-Ab-1/ GM-Tg-mg-SE1382-Ab-2 | Anti-Mouse WNT10B monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1382-Ab-1/ GM-Tg-cynog-SE1382-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WNT10B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1382-Ab-1/ GM-Tg-felg-SE1382-Ab-2 | Anti-Feline WNT10B monoclonal antibody | Feline |
| GM-Tg-cang-SE1382-Ab-1/ GM-Tg-cang-SE1382-Ab-2 | Anti-Canine WNT10B monoclonal antibody | Canine |
| GM-Tg-bovg-SE1382-Ab-1/ GM-Tg-bovg-SE1382-Ab-2 | Anti-Bovine WNT10B monoclonal antibody | Bovine |
| GM-Tg-equg-SE1382-Ab-1/ GM-Tg-equg-SE1382-Ab-2 | Anti-Equine WNT10B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1382-Ab-1/ GM-Tg-hg-SE1382-Ab-2; GM-Tg-rg-SE1382-Ab-1/ GM-Tg-rg-SE1382-Ab-2; GM-Tg-mg-SE1382-Ab-1/ GM-Tg-mg-SE1382-Ab-2; GM-Tg-cynog-SE1382-Ab-1/ GM-Tg-cynog-SE1382-Ab-2; GM-Tg-felg-SE1382-Ab-1/ GM-Tg-felg-SE1382-Ab-2; GM-Tg-cang-SE1382-Ab-1/ GM-Tg-cang-SE1382-Ab-2; GM-Tg-bovg-SE1382-Ab-1/ GM-Tg-bovg-SE1382-Ab-2; GM-Tg-equg-SE1382-Ab-1/ GM-Tg-equg-SE1382-Ab-2 |
| Products Name | Anti-WNT10B monoclonal antibody |
| Format | mab |
| Target Name | WNT10B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-WNT10B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1382-Ag-1 | Recombinant multi-species WN10B/ WNT10B/ SHFM6 protein |
| Cytokine | GM-Tg-g-SE1382-Ag-1 | wingless-type MMTV integration site family, member 10B (WNT10B) protein |
| ORF Viral Vector | pGMLP003631 | human WNT10B Lentivirus plasmid |
| ORF Viral Vector | vGMLP003631 | human WNT10B Lentivirus particle |
| ORF Viral Vector | pGMLPm003834 | mouse Wnt10b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003834 | mouse Wnt10b Lentivirus particle |
Target information
| Target ID | GM-SE1382 |
| Target Name | WNT10B |
| Gene ID | 7480,22410,315294,708906,486561,101093948,539337,100051649 |
| Gene Symbol and Synonyms | SHFM6,STHAG8,WNT-12,WNT10B,Wnt12 |
| Uniprot Accession | O00744 |
| Uniprot Entry Name | WN10B_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000169884 |
| Target Classification | N/A |
The target: WNT10B, gene name: WNT10B, also named as SHFM6, STHAG8, WNT-12. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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