Anti-TENR/ TNR/ TN-R functional antibody

Anti-TENR/ TNR/ TN-R functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TNR/TNR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1346-Ab-1/ GM-Tg-hg-SE1346-Ab-2Anti-Human TNR monoclonal antibodyHuman
GM-Tg-rg-SE1346-Ab-1/ GM-Tg-rg-SE1346-Ab-2Anti-Rat TNR monoclonal antibodyRat
GM-Tg-mg-SE1346-Ab-1/ GM-Tg-mg-SE1346-Ab-2Anti-Mouse TNR monoclonal antibodyMouse
GM-Tg-cynog-SE1346-Ab-1/ GM-Tg-cynog-SE1346-Ab-2Anti-Cynomolgus/ Rhesus macaque TNR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1346-Ab-1/ GM-Tg-felg-SE1346-Ab-2Anti-Feline TNR monoclonal antibodyFeline
GM-Tg-cang-SE1346-Ab-1/ GM-Tg-cang-SE1346-Ab-2Anti-Canine TNR monoclonal antibodyCanine
GM-Tg-bovg-SE1346-Ab-1/ GM-Tg-bovg-SE1346-Ab-2Anti-Bovine TNR monoclonal antibodyBovine
GM-Tg-equg-SE1346-Ab-1/ GM-Tg-equg-SE1346-Ab-2Anti-Equine TNR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1346-Ab-1/ GM-Tg-hg-SE1346-Ab-2; GM-Tg-rg-SE1346-Ab-1/ GM-Tg-rg-SE1346-Ab-2;
GM-Tg-mg-SE1346-Ab-1/ GM-Tg-mg-SE1346-Ab-2; GM-Tg-cynog-SE1346-Ab-1/ GM-Tg-cynog-SE1346-Ab-2;
GM-Tg-felg-SE1346-Ab-1/ GM-Tg-felg-SE1346-Ab-2; GM-Tg-cang-SE1346-Ab-1/ GM-Tg-cang-SE1346-Ab-2;
GM-Tg-bovg-SE1346-Ab-1/ GM-Tg-bovg-SE1346-Ab-2; GM-Tg-equg-SE1346-Ab-1/ GM-Tg-equg-SE1346-Ab-2
Products NameAnti-TNR monoclonal antibody
Formatmab
Target NameTNR
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1346-Ag-1Recombinant multi-species TENR/ TNR/ TN-R protein


    Target information

    Target IDGM-SE1346
    Target NameTNR
    Gene ID7143,21960,25567,708707,490334,101096629,526409,100061691
    Gene Symbol and SynonymsJ1-tenascin,J1NRM,janusin,NEDSTO,restrictin,TN-R,TNR
    Uniprot AccessionQ92752,Q05546
    Uniprot Entry NameTENR_HUMAN,TENR_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000116147
    Target ClassificationN/A

    The target: TNR, gene name: TNR, also named as TN-R. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.