- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-NRTN/ NTN functional antibody
Anti-NRTN/ NTN functional antibody for cell culture, ELISA & in-vivo assay
Go to NRTN/NRTN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1137-Ab-1/ GM-Tg-hg-SE1137-Ab-2 | Anti-Human NRTN monoclonal antibody | Human |
| GM-Tg-rg-SE1137-Ab-1/ GM-Tg-rg-SE1137-Ab-2 | Anti-Rat NRTN monoclonal antibody | Rat |
| GM-Tg-mg-SE1137-Ab-1/ GM-Tg-mg-SE1137-Ab-2 | Anti-Mouse NRTN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1137-Ab-1/ GM-Tg-cynog-SE1137-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRTN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1137-Ab-1/ GM-Tg-felg-SE1137-Ab-2 | Anti-Feline NRTN monoclonal antibody | Feline |
| GM-Tg-cang-SE1137-Ab-1/ GM-Tg-cang-SE1137-Ab-2 | Anti-Canine NRTN monoclonal antibody | Canine |
| GM-Tg-bovg-SE1137-Ab-1/ GM-Tg-bovg-SE1137-Ab-2 | Anti-Bovine NRTN monoclonal antibody | Bovine |
| GM-Tg-equg-SE1137-Ab-1/ GM-Tg-equg-SE1137-Ab-2 | Anti-Equine NRTN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1137-Ab-1/ GM-Tg-hg-SE1137-Ab-2; GM-Tg-rg-SE1137-Ab-1/ GM-Tg-rg-SE1137-Ab-2; GM-Tg-mg-SE1137-Ab-1/ GM-Tg-mg-SE1137-Ab-2; GM-Tg-cynog-SE1137-Ab-1/ GM-Tg-cynog-SE1137-Ab-2; GM-Tg-felg-SE1137-Ab-1/ GM-Tg-felg-SE1137-Ab-2; GM-Tg-cang-SE1137-Ab-1/ GM-Tg-cang-SE1137-Ab-2; GM-Tg-bovg-SE1137-Ab-1/ GM-Tg-bovg-SE1137-Ab-2; GM-Tg-equg-SE1137-Ab-1/ GM-Tg-equg-SE1137-Ab-2 |
| Products Name | Anti-NRTN monoclonal antibody |
| Format | mab |
| Target Name | NRTN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRTN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1137-Ag-1 | Recombinant multi-species NRTN/ NTN protein |
| Cytokine | GM-Tg-g-SE1137-Ag-1 | neurturin (NRTN) protein |
| ORF Viral Vector | vGMLP001825 | human Nrtn Lentivirus particle |
| ORF Viral Vector | pGMLP001825 | human Nrtn Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000304 | mouse Nrtn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000304 | mouse Nrtn Lentivirus particle |
Target information
| Target ID | GM-SE1137 |
| Target Name | NRTN |
| Gene ID | 4902,18188,84423,697336,109493852,525562,111774192 |
| Gene Symbol and Synonyms | NRTN,NTN |
| Uniprot Accession | Q99748 |
| Uniprot Entry Name | NRTN_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171119 |
| Target Classification | N/A |
The target: NRTN, gene name: NRTN, also named as NTN. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
