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Anti-IL36A/ FIL1/ FIL1(EPSILON) functional antibody
Anti-IL36A/ FIL1/ FIL1(EPSILON) functional antibody for cell culture, ELISA & in-vivo assay
Go to IL36A/IL36A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1029-Ab-1/ GM-Tg-hg-SE1029-Ab-2 | Anti-Human IL36A monoclonal antibody | Human |
| GM-Tg-rg-SE1029-Ab-1/ GM-Tg-rg-SE1029-Ab-2 | Anti-Rat IL36A monoclonal antibody | Rat |
| GM-Tg-mg-SE1029-Ab-1/ GM-Tg-mg-SE1029-Ab-2 | Anti-Mouse IL36A monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1029-Ab-1/ GM-Tg-cynog-SE1029-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL36A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1029-Ab-1/ GM-Tg-felg-SE1029-Ab-2 | Anti-Feline IL36A monoclonal antibody | Feline |
| GM-Tg-cang-SE1029-Ab-1/ GM-Tg-cang-SE1029-Ab-2 | Anti-Canine IL36A monoclonal antibody | Canine |
| GM-Tg-bovg-SE1029-Ab-1/ GM-Tg-bovg-SE1029-Ab-2 | Anti-Bovine IL36A monoclonal antibody | Bovine |
| GM-Tg-equg-SE1029-Ab-1/ GM-Tg-equg-SE1029-Ab-2 | Anti-Equine IL36A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1029-Ab-1/ GM-Tg-hg-SE1029-Ab-2; GM-Tg-rg-SE1029-Ab-1/ GM-Tg-rg-SE1029-Ab-2; GM-Tg-mg-SE1029-Ab-1/ GM-Tg-mg-SE1029-Ab-2; GM-Tg-cynog-SE1029-Ab-1/ GM-Tg-cynog-SE1029-Ab-2; GM-Tg-felg-SE1029-Ab-1/ GM-Tg-felg-SE1029-Ab-2; GM-Tg-cang-SE1029-Ab-1/ GM-Tg-cang-SE1029-Ab-2; GM-Tg-bovg-SE1029-Ab-1/ GM-Tg-bovg-SE1029-Ab-2; GM-Tg-equg-SE1029-Ab-1/ GM-Tg-equg-SE1029-Ab-2 |
| Products Name | Anti-IL36A monoclonal antibody |
| Format | mab |
| Target Name | IL36A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL36A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1029-Ag-1 | Recombinant multi-species IL36A/ FIL1/ FIL1(EPSILON) protein |
| Cytokine | GM-Tg-g-SE1029-Ag-1 | IL-1 F6 (IL36A) protein |
Target information
| Target ID | GM-SE1029 |
| Target Name | IL36A |
| Gene ID | 27179,296541,705136 |
| Gene Symbol and Synonyms | FIL1,FIL1(EPSILON),FIL1E,IL-1F6,IL1(EPSILON),IL1F6,IL36A |
| Uniprot Accession | Q9UHA7 |
| Uniprot Entry Name | IL36A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136694 |
| Target Classification | N/A |
The target: IL36A, gene name: IL36A, also named as FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6. The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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