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Anti-GRP/ BN-10/ preproGRP functional antibody
Anti-GRP/ BN-10/ preproGRP functional antibody for cell culture, ELISA & in-vivo assay
Go to GRP/GRP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0960-Ab-1/ GM-Tg-hg-SE0960-Ab-2 | Anti-Human GRP monoclonal antibody | Human |
| GM-Tg-rg-SE0960-Ab-1/ GM-Tg-rg-SE0960-Ab-2 | Anti-Rat GRP monoclonal antibody | Rat |
| GM-Tg-mg-SE0960-Ab-1/ GM-Tg-mg-SE0960-Ab-2 | Anti-Mouse GRP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0960-Ab-1/ GM-Tg-cynog-SE0960-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0960-Ab-1/ GM-Tg-felg-SE0960-Ab-2 | Anti-Feline GRP monoclonal antibody | Feline |
| GM-Tg-cang-SE0960-Ab-1/ GM-Tg-cang-SE0960-Ab-2 | Anti-Canine GRP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0960-Ab-1/ GM-Tg-bovg-SE0960-Ab-2 | Anti-Bovine GRP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0960-Ab-1/ GM-Tg-equg-SE0960-Ab-2 | Anti-Equine GRP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0960-Ab-1/ GM-Tg-hg-SE0960-Ab-2; GM-Tg-rg-SE0960-Ab-1/ GM-Tg-rg-SE0960-Ab-2; GM-Tg-mg-SE0960-Ab-1/ GM-Tg-mg-SE0960-Ab-2; GM-Tg-cynog-SE0960-Ab-1/ GM-Tg-cynog-SE0960-Ab-2; GM-Tg-felg-SE0960-Ab-1/ GM-Tg-felg-SE0960-Ab-2; GM-Tg-cang-SE0960-Ab-1/ GM-Tg-cang-SE0960-Ab-2; GM-Tg-bovg-SE0960-Ab-1/ GM-Tg-bovg-SE0960-Ab-2; GM-Tg-equg-SE0960-Ab-1/ GM-Tg-equg-SE0960-Ab-2 |
| Products Name | Anti-GRP monoclonal antibody |
| Format | mab |
| Target Name | GRP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0960-Ag-1 | Recombinant multi-species GRP/ BN-10/ preproGRP protein |
| ORF Viral Vector | vGMLP002238 | human GRP Lentivirus particle |
| ORF Viral Vector | pGMLP002238 | human GRP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001039 | mouse Grp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001039 | mouse Grp Lentivirus particle |
Target information
| Target ID | GM-SE0960 |
| Target Name | GRP |
| Gene ID | 2922,225642,171101,696983,610154,109493482,615323,100050124 |
| Gene Symbol and Synonyms | BLP,BN,GRP,GRP-10,preproGRP,proGRP |
| Uniprot Accession | P07492,P24393,P08989,Q863C3 |
| Uniprot Entry Name | GRP_HUMAN,GRP_RAT,GRP_CANLF,GRP_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000134443 |
| Target Classification | N/A |
The target: GRP, gene name: GRP, also named as BN-10, preproGRP, proGRP, GRP. This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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